Pablo De Ioannes
Overview
Explore the profile of Pablo De Ioannes including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
477
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Recent Articles
1.
Whedon S, Lee K, Wang Z, Zahn E, Lu C, Yapa Abeywardana M, et al.
J Am Chem Soc
. 2024 Nov;
146(49):33914-33927.
PMID: 39585806
Reversible modification of the histone H3 N-terminal tail is critical in regulating the chromatin structure, gene expression, and cell states, while its dysregulation contributes to disease pathogenesis. Understanding the crosstalk...
2.
Lopez V, Valencia-Sanchez M, Abini-Agbomson S, Thomas J, Lee R, De Ioannes P, et al.
Nature
. 2024 Nov;
636(8043):755-761.
PMID: 39537923
Epigenetic inheritance of silent chromatin domains is fundamental to cellular memory during embryogenesis, but it must overcome the dilution of repressive histone modifications during DNA replication. One such modification, histone...
3.
Whedon S, Lee K, Wang Z, Zahn E, Lu C, Yapa-Abeywardana M, et al.
bioRxiv
. 2024 Oct;
PMID: 39372790
Reversible modification of the histone H3 N-terminal tail is critical in regulating chromatin structure, gene expression, and cell states, while its dysregulation contributes to disease pathogenesis. Understanding the crosstalk between...
4.
Abini-Agbomson S, Gretarsson K, Shih R, Hsieh L, Lou T, De Ioannes P, et al.
Mol Cell
. 2023 Aug;
83(16):2872-2883.e7.
PMID: 37595555
SUV420H1 di- and tri-methylates histone H4 lysine 20 (H4K20me2/H4K20me3) and plays crucial roles in DNA replication, repair, and heterochromatin formation. It is dysregulated in several cancers. Many of these processes...
5.
Thomas J, Valencia-Sanchez M, Tamburri S, Gloor S, Rustichelli S, Godinez-Lopez V, et al.
Sci Adv
. 2023 Aug;
9(32):eadg9832.
PMID: 37556531
Histone H2A lysine 119 (H2AK119Ub) is monoubiquitinated by Polycomb repressive complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex (PR-DUB). PR-DUB cleaves H2AK119Ub to restrict focal H2AK119Ub at Polycomb target...
6.
Abini-Agbomson S, Gretarsson K, Shih R, Hsieh L, Lou T, De Ioannes P, et al.
bioRxiv
. 2023 Mar;
PMID: 36993485
The intricate regulation of chromatin plays a key role in controlling genome architecture and accessibility. Histone lysine methyltransferases regulate chromatin by catalyzing the methylation of specific histone residues but are...
7.
Thomas J, Valencia-Sanchez M, Tamburri S, Gloor S, Rustichelli S, Godinez-Lopez V, et al.
bioRxiv
. 2023 Mar;
PMID: 36865140
One Sentence Summary: We reveal the molecular mechanism of nucleosomal H2AK119Ub deubiquitination by human BAP1/ASXL1.
8.
Bryson T, De Ioannes P, Valencia-Sanchez M, Henikoff J, Talbert P, Lee R, et al.
Mol Cell
. 2022 Nov;
82(23):4458-4470.e5.
PMID: 36370708
The two doublet histones of Marseillevirus are distantly related to the four eukaryotic core histones and wrap 121 base pairs of DNA to form remarkably similar nucleosomes. By permeabilizing Marseillevirus...
9.
Barry R, Sacco O, Mameri A, Stojaspal M, Kartsonis W, Shah P, et al.
Genes Dev
. 2022 Feb;
36(5-6):313-330.
PMID: 35210222
In mammals, the conserved telomere binding protein Rap1 serves a diverse set of nontelomeric functions, including activation of the NF-kB signaling pathway, maintenance of metabolic function in vivo, and transcriptional...
10.
Valencia-Sanchez M, Abini-Agbomson S, Wang M, Lee R, Vasilyev N, Zhang J, et al.
Nat Struct Mol Biol
. 2021 Apr;
28(5):413-417.
PMID: 33927388
Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic...