Karim-Jean Armache
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Explore the profile of Karim-Jean Armache including associated specialties, affiliations and a list of published articles.
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31
Citations
1410
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Recent Articles
1.
Whedon S, Lee K, Wang Z, Zahn E, Lu C, Yapa Abeywardana M, et al.
J Am Chem Soc
. 2024 Nov;
146(49):33914-33927.
PMID: 39585806
Reversible modification of the histone H3 N-terminal tail is critical in regulating the chromatin structure, gene expression, and cell states, while its dysregulation contributes to disease pathogenesis. Understanding the crosstalk...
2.
Maroni M, Barton M, Lynch K, Deshwar A, Campbell P, Millard J, et al.
medRxiv
. 2024 Nov;
PMID: 39574879
Individuals with monoallelic pathogenic variants in the histone lysine methyltransferase DOT1L display global developmental delay and varying congenital anomalies. However, the impact of monoallelic loss of remains unclear. Here, we...
3.
Lopez V, Valencia-Sanchez M, Abini-Agbomson S, Thomas J, Lee R, De Ioannes P, et al.
Nature
. 2024 Nov;
636(8043):755-761.
PMID: 39537923
Epigenetic inheritance of silent chromatin domains is fundamental to cellular memory during embryogenesis, but it must overcome the dilution of repressive histone modifications during DNA replication. One such modification, histone...
4.
Whedon S, Lee K, Wang Z, Zahn E, Lu C, Yapa-Abeywardana M, et al.
bioRxiv
. 2024 Oct;
PMID: 39372790
Reversible modification of the histone H3 N-terminal tail is critical in regulating chromatin structure, gene expression, and cell states, while its dysregulation contributes to disease pathogenesis. Understanding the crosstalk between...
5.
Gretarsson K, Abini-Agbomson S, Gloor S, Weinberg D, McCuiston J, Kumary V, et al.
Sci Adv
. 2024 Aug;
10(35):eadp0975.
PMID: 39196936
During tumor development, promoter CpG islands that are normally silenced by Polycomb repressive complexes (PRCs) become DNA-hypermethylated. The molecular mechanism by which de novo DNA methyltransferase(s) [DNMT(s)] catalyze CpG methylation...
6.
Gretarsson K, Abini-Agbomson S, Gloor S, Weinberg D, McCuiston J, Kumary V, et al.
bioRxiv
. 2024 Apr;
PMID: 38562823
During tumor development, promoter CpG islands (CGIs) that are normally silenced by Polycomb repressive complexes (PRCs) become DNA hypermethylated. The molecular mechanism by which DNA methyltransferase(s) catalyze CpG methylation at...
7.
Chapman J, Paukner M, Leser M, Teng K, Koide S, Holder M, et al.
Anal Chem
. 2023 Dec;
95(50):18316-18325.
PMID: 38049117
Correlating the structure and dynamics of proteins with biological function is critical to understanding normal and dysfunctional cellular mechanisms. We describe a quantitative method of hydroxyl radical generation via Fe(II)-ethylenediaminetetraacetic...
8.
Talbert P, Henikoff S, Armache K
Trends Biochem Sci
. 2023 Sep;
48(12):1071-1082.
PMID: 37777391
Giant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase (pATPase)...
9.
Abini-Agbomson S, Gretarsson K, Shih R, Hsieh L, Lou T, De Ioannes P, et al.
Mol Cell
. 2023 Aug;
83(16):2872-2883.e7.
PMID: 37595555
SUV420H1 di- and tri-methylates histone H4 lysine 20 (H4K20me2/H4K20me3) and plays crucial roles in DNA replication, repair, and heterochromatin formation. It is dysregulated in several cancers. Many of these processes...
10.
Thomas J, Valencia-Sanchez M, Tamburri S, Gloor S, Rustichelli S, Godinez-Lopez V, et al.
Sci Adv
. 2023 Aug;
9(32):eadg9832.
PMID: 37556531
Histone H2A lysine 119 (H2AK119Ub) is monoubiquitinated by Polycomb repressive complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex (PR-DUB). PR-DUB cleaves H2AK119Ub to restrict focal H2AK119Ub at Polycomb target...