Pablo De Ioannes
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Explore the profile of Pablo De Ioannes including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
477
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Recent Articles
11.
Valencia-Sanchez M, De Ioannes P, Wang M, Truong D, Lee R, Armache J, et al.
Science
. 2021 Jan;
371(6527).
PMID: 33479126
Dot1 (disruptor of telomeric silencing-1), the histone H3 lysine 79 (H3K79) methyltransferase, is conserved throughout evolution, and its deregulation is found in human leukemias. Here, we provide evidence that acetylation...
12.
De Ioannes P, Leon V, Kuang Z, Wang M, Boeke J, Hochwagen A, et al.
Nat Commun
. 2019 Jul;
10(1):2894.
PMID: 31263106
The Origin Recognition Complex (ORC) is essential for replication, heterochromatin formation, telomere maintenance and genome stability in eukaryotes. Here we present the structure of the yeast Orc1 BAH domain bound...
13.
Valencia-Sanchez M, De Ioannes P, Wang M, Vasilyev N, Chen R, Nudler E, et al.
Mol Cell
. 2019 Apr;
74(5):1010-1019.e6.
PMID: 30981630
The essential histone H3 lysine 79 methyltransferase Dot1L regulates transcription and genomic stability and is deregulated in leukemia. The activity of Dot1L is stimulated by mono-ubiquitination of histone H2B on...
14.
Charlier C, Bouvignies G, Pelupessy P, Walrant A, Marquant R, Kozlov M, et al.
J Am Chem Soc
. 2017 Aug;
139(35):12219-12227.
PMID: 28780862
Many intrinsically disordered proteins (IDPs) and protein regions (IDRs) engage in transient, yet specific, interactions with a variety of protein partners. Often, if not always, interactions with a protein partner...
15.
Arancibia S, Espinoza C, Salazar F, Del Campo M, Tampe R, Zhong T, et al.
PLoS One
. 2014 Jan;
9(1):e87240.
PMID: 24466345
Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as immunomodulatory proteins with proven anti-cancer properties. The biodiversity of hemocyanins has promoted interest in identifying new anti-cancer candidates with...
16.
De Ioannes P, Malu S, Cortes P, Aggarwal A
Cell Rep
. 2012 Dec;
2(6):1505-12.
PMID: 23219551
DNA ligase IV (LigIV) and Artemis are central components of the nonhomologous end-joining (NHEJ) machinery that is required for V(D)J recombination and the maintenance of genomic integrity in mammalian cells....
17.
Ferrage F, Dutta K, Nistal-Villan E, Patel J, Sanchez-Aparicio M, De Ioannes P, et al.
Structure
. 2012 Oct;
20(12):2048-61.
PMID: 23063562
RIG-I is a cytosolic sensor of viral RNA, comprised of two N-terminal CARDs followed by helicase and C-terminal regulatory domains (helicase-CTD). Viral RNA binds to the helicase-CTD and "exposes" the...
18.
Malu S, De Ioannes P, Kozlov M, Greene M, Francis D, Hanna M, et al.
J Exp Med
. 2012 Apr;
209(5):955-63.
PMID: 22529269
Artemis is an endonuclease that opens coding hairpin ends during V(D)J recombination and has critical roles in postirradiation cell survival. A direct role for the C-terminal region of Artemis in...
19.
Del Campo M, Arancibia S, Nova E, Salazar F, Gonzalez A, Moltedo B, et al.
Rev Med Chil
. 2011 Jul;
139(2):236-46.
PMID: 21773663
Hemocyanins, the giant oxygen transporter glycoproteins of diverse mollusks, are xenogenic to the mammalian immune system and they display a remarkable immuno-genicity. Therefore they are ideal non-specific immunostimulants to treat...
20.
De Ioannes P, Escalante C, Aggarwal A
Nucleic Acids Res
. 2011 May;
39(16):7300-7.
PMID: 21596780
Interferon regulatory factors IRF-3 and IRF-7 are transcription factors essential in the activation of interferon-β (IFN-β) gene in response to viral infections. Although, both proteins recognize the same consensus IRF...