Pabitra K Parua
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Explore the profile of Pabitra K Parua including associated specialties, affiliations and a list of published articles.
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14
Citations
332
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Recent Articles
1.
Cossa G, Parua P, Eilers M, Fisher R
Genes Dev
. 2021 Apr;
35(9-10):658-676.
PMID: 33888562
The transcription cycle of RNA polymerase II (RNAPII) is governed at multiple points by opposing actions of cyclin-dependent kinases (CDKs) and protein phosphatases, in a process with similarities to the...
2.
Parua P, Kalan S, Benjamin B, Sanso M, Fisher R
Nat Commun
. 2020 Aug;
11(1):4338.
PMID: 32859893
Reversible phosphorylation of Pol II and accessory factors helps order the transcription cycle. Here, we define two kinase-phosphatase switches that operate at different points in human transcription. Cdk9/cyclin T1 (P-TEFb)...
3.
Parua P, Fisher R
Nat Chem Biol
. 2020 Jun;
16(7):716-724.
PMID: 32572259
Largely non-overlapping sets of cyclin-dependent kinases (CDKs) regulate cell division and RNA polymerase II (Pol II)-dependent transcription. Here we review the molecular mechanisms by which specific CDKs are thought to...
4.
Sanso M, Parua P, Pinto D, Svensson J, Page V, Bitton D, et al.
Nucleic Acids Res
. 2020 Jun;
48(13):7154-7168.
PMID: 32496538
Mono-ubiquitylation of histone H2B (H2Bub1) and phosphorylation of elongation factor Spt5 by cyclin-dependent kinase 9 (Cdk9) occur during transcription by RNA polymerase II (RNAPII), and are mutually dependent in fission...
5.
Parua P, Booth G, Sanso M, Benjamin B, Tanny J, Lis J, et al.
Nature
. 2018 Jun;
558(7710):460-464.
PMID: 29899453
The end of the RNA polymerase II (Pol II) transcription cycle is strictly regulated to prevent interference between neighbouring genes and to safeguard transcriptome integrity . The accumulation of Pol...
6.
Booth G, Parua P, Sanso M, Fisher R, Lis J
Nat Commun
. 2018 Feb;
9(1):543.
PMID: 29416031
Post-translational modifications of the transcription elongation complex provide mechanisms to fine-tune gene expression, yet their specific impacts on RNA polymerase II regulation remain difficult to ascertain. Here, in Schizosaccharomyces pombe,...
7.
Yeast 14-3-3 protein functions as a comodulator of transcription by inhibiting coactivator functions
Parua P, Dombek K, Young E
J Biol Chem
. 2014 Oct;
289(51):35542-60.
PMID: 25355315
In eukaryotes combinatorial activation of transcription is an important component of gene regulation. In the budding yeast Saccharomyces cerevisiae, Adr1-Cat8 and Adr1-Oaf1/Pip2 are pairs of activators that act together to...
8.
Parua P, Young E
Eukaryot Cell
. 2013 Oct;
13(1):21-30.
PMID: 24142105
Evolutionarily conserved 14-3-3 proteins have important functions as dimers in numerous cellular signaling processes, including regulation of transcription. Yeast 14-3-3 proteins, known as Bmh, inhibit a post-DNA binding step in...
9.
Braun K, Parua P, Dombek K, Miner G, Young E
Mol Cell Biol
. 2012 Dec;
33(4):712-24.
PMID: 23207903
Adr1 and Cat8 are nutrient-regulated transcription factors in Saccharomyces cerevisiae that coactivate genes necessary for growth in the absence of a fermentable carbon source. Transcriptional activation by Adr1 is dependent...
10.
Young E, Zhang C, Shokat K, Parua P, Braun K
J Biol Chem
. 2012 Jul;
287(34):29021-34.
PMID: 22761425
AMP-activated protein kinase, the "energy sensor of the cell," responds to low cellular energy stores by regulating enzymes and transcription factors that allow the cell to adapt to limiting nutritional...