Jason C Tanny
Overview
Explore the profile of Jason C Tanny including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
1081
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Recent Articles
1.
The Rtf1/Prf1-dependent histone modification axis counteracts multi-drug resistance in fission yeast
Chen J, Moy C, Page V, Monnin C, El-Hajj Z, Avizonis D, et al.
Life Sci Alliance
. 2024 Mar;
7(6).
PMID: 38514187
RNA polymerase II transcription elongation directs an intricate pattern of histone modifications. This pattern includes a regulatory cascade initiated by the elongation factor Rtf1, leading to monoubiquitylation of histone H2B,...
2.
MacKinnon S, Page V, Chen J, Shariat-Panahi A, Martin R, Hebert T, et al.
PLoS Genet
. 2023 Nov;
19(11):e1010492.
PMID: 37939109
Heterochromatin is a condensed chromatin structure that represses transcription of repetitive DNA elements and developmental genes, and is required for genome stability. Paradoxically, transcription of heterochromatic sequences is required for...
3.
Bourque K, Jones-Tabah J, Petrin D, Martin R, Tanny J, Hebert T
Sci Rep
. 2023 Jul;
13(1):12248.
PMID: 37507481
The inaccessibility of human cardiomyocytes significantly hindered years of cardiovascular research efforts. To overcome these limitations, non-human cell sources were used as proxies to study heart function and associated diseases....
4.
Khan S, Martin R, Bayne A, Petrin D, Bourque K, Jones-Tabah J, et al.
J Biol Chem
. 2023 Feb;
299(4):103064.
PMID: 36841480
Gβγ subunits mediate many different signaling processes in various compartments of the cell, including the nucleus. To gain insight into the functions of nuclear Gβγ signaling, we investigated the functional...
5.
Chen J, Stermer D, Tanny J
Front Cell Dev Biol
. 2022 Sep;
10:968398.
PMID: 36105353
Histone ubiquitylation is a critical part of both active and repressed transcriptional states, and lies at the heart of DNA damage repair signaling. The histone residues targeted for ubiquitylation are...
6.
Jones-Tabah J, Martin R, Chen J, Tanny J, Clarke P, Hebert T
Cell Signal
. 2022 Jan;
91:110226.
PMID: 34974082
The activity of striatal medium-spiny projection neurons is regulated by D1 and D2 dopamine receptors. The D1 receptor (D1R) is a Gα-coupled GPCR which activates a cAMP/PKA/DARPP-32 signalling cascade that...
7.
Jones-Tabah J, Martin R, Tanny J, Clarke P, Hebert T
Mol Pharmacol
. 2021 Sep;
100(6):526-539.
PMID: 34503973
Genetically encoded biosensors can be used to track signaling events in living cells by measuring changes in fluorescence emitted by one or more fluorescent proteins. Here, we describe the use...
8.
Nassour H, Hoang T, Martin R, Dallagnol J, Billard E, Letourneau M, et al.
J Biol Chem
. 2021 Aug;
297(3):101057.
PMID: 34389356
Over the last decade, the urotensinergic system, composed of one G protein-coupled receptor and two endogenous ligands, has garnered significant attention as a promising new target for the treatment of...
9.
Pinto D, Page V, Fisher R, Tanny J
Curr Genet
. 2021 Jun;
67(5):695-705.
PMID: 34089069
Co-transcriptional histone modifications are a ubiquitous feature of RNA polymerase II (RNAPII) transcription, with profound but incompletely understood effects on gene expression. Unlike the covalent marks found at promoters, which...
10.
Jones-Tabah J, Mohammad H, Hadj-Youssef S, Kim L, Martin R, Benaliouad F, et al.
Sci Rep
. 2020 Sep;
10(1):14426.
PMID: 32879346
As with many G protein-coupled receptors (GPCRs), the signalling pathways regulated by the dopamine D1 receptor (D1R) are dynamic, cell type-specific, and can change in the face of disease or...