P T van der Saag
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Explore the profile of P T van der Saag including associated specialties, affiliations and a list of published articles.
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133
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3069
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Recent Articles
21.
van Puijenbroek A, Wissink S, van der Saag P, Peppelenbosch M
Cytokine
. 1999 Mar;
11(2):104-10.
PMID: 10089130
Tumour necrosis factor (TNF) is a key regulator of inflammation and immunity. The cellular effects exerted by TNF depend, apart from NF-kappaB-directed gene transcription, largely on its ability to activate...
22.
van Tilborg P, Mulder F, de Backer M, Nair M, van Heerde E, Folkers G, et al.
Biochemistry
. 1999 Feb;
38(7):1951-6.
PMID: 10026278
The all-trans retinoic acid and 9-cis retinoic acid receptors (RAR and RXR, respectively) belong to a family of ligand inducible transcription factors, which exert their effect via binding to hormone...
23.
van Pelt A, de Rooij D, van der Burg B, van der Saag P, Gustafsson J, Kuiper G
Endocrinology
. 1999 Jan;
140(1):478-83.
PMID: 9886860
The recently discovered estrogen receptor-beta (ERbeta) is expressed in rodent and human testes. To obtain insight in the physiological role of ERbeta we have investigated the cell type-specific expression pattern...
24.
Pijnappel W, Folkers G, de Jonge W, Verdegem P, de Laat S, Lugtenburg J, et al.
Proc Natl Acad Sci U S A
. 1998 Dec;
95(26):15424-9.
PMID: 9860984
We report identification of 9-cis-4-oxo-retinoic acid (9-cis-4-oxo-RA) as an in vivo retinoid metabolite in Xenopus embryos. 9-Cis-4-oxo-RA bound receptors (RARs) alpha, beta, and gamma as well as retinoid X receptors...
25.
Sonneveld E, van der Saag P
Int J Vitam Nutr Res
. 1998 Dec;
68(6):404-10.
PMID: 9857269
Vitamin A derived retinoids, including all-trans retinoic acid (RA), play an important role in regulating cellular growth and differentiation. Biological activities of retinoids are mediated through interactions with two classes...
26.
Folkers G, van der Burg B, van der Saag P
J Biol Chem
. 1998 Nov;
273(48):32200-12.
PMID: 9822698
Expression of retinoic acid receptor beta (RARbeta) is spatially and temporally restricted during embryonal development. Also during retinoic acid (RA)-dependent embryonal carcinoma (EC) cell differentiation, RARbeta expression is initially up-regulated,...
27.
Maden M, Sonneveld E, van der Saag P, Gale E
Development
. 1998 Oct;
125(21):4133-44.
PMID: 9753668
The aim of these experiments was to determine the endogenous distribution of retinoic acid (RA) across a wide range of embryonic stages in the chick embryo. By high pressure liquid...
28.
Gaemers I, Sonneveld E, van Pelt A, Schrans B, Themmen A, van der Saag P, et al.
Endocrinology
. 1998 Sep;
139(10):4269-76.
PMID: 9751509
Retinoid X receptors (RXRs) are key regulators in retinoid signaling. Knowledge about the effects of 9-cis-retinoic acid (9-cis-RA), the natural ligand for the RXRs, may also provide insight in the...
29.
Kuiper G, Lemmen J, Carlsson B, Corton J, Safe S, van der Saag P, et al.
Endocrinology
. 1998 Sep;
139(10):4252-63.
PMID: 9751507
The rat, mouse and human estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal ligand-binding domain and in the N-terminal transactivation domain....
30.
Sonneveld E, van den Brink C, van der Leede B, Schulkes R, Petkovich M, van der Burg B, et al.
Cell Growth Differ
. 1998 Aug;
9(8):629-37.
PMID: 9716180
We report on the isolation of a cytochrome P450 (CYP)-like retinoic acid (RA) 4-hydroxylase cDNA from T-47D human breast cancer cells that is identical to the recently cloned hCYP26, which...