P T van der Saag
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Explore the profile of P T van der Saag including associated specialties, affiliations and a list of published articles.
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133
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3069
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Recent Articles
11.
de Laat S, Boonstra J, Defize L, Kruijer W, van der Saag P, Tertoolen L, et al.
Int J Dev Biol
. 2000 Feb;
43(7):681-91.
PMID: 10668978
Signalling between cells in the developing vertebrate embryo is essential for normal embryonic development. In the mid 1970's, signal transduction research started at the Hubrecht Laboratory with special emphasis on...
12.
Wissink S, Meijer O, Pearce D, van der Burg B, van der Saag P
J Biol Chem
. 2000 Jan;
275(2):1321-6.
PMID: 10625680
Dysregulation of the serotonergic system and abnormalities of the hypothalamic-pituitary-adrenal axis function have been implicated to be involved in neuropsychiatric disorders. Serotonin-1A receptors have been shown to be suppressed by...
13.
KESTER H, Blanchetot C, den Hertog J, van der Saag P, van der Burg B
J Biol Chem
. 1999 Sep;
274(39):27439-47.
PMID: 10488076
TGF-beta-stimulated clone-22 (TSC-22) encodes a leucine zipper-containing protein that is highly conserved during evolution. Two homologues are known that share a similar leucine zipper domain and another conserved domain (designated...
14.
Sonneveld E, van den Brink C, Tertoolen L, van der Burg B, van der Saag P
Dev Biol
. 1999 Sep;
213(2):390-404.
PMID: 10479456
Besides nuclear retinoid receptors and cellular retinoid binding proteins also retinoic acid (RA)-synthesizing enzymes (using all-trans-retinal as substrate) and RA-catabolizing enzymes (producing hydroxylated products) may explain the specific effects of...
15.
van Puijenbroek A, van der Saag P, Coffer P
Exp Cell Res
. 1999 Sep;
251(2):465-76.
PMID: 10471331
Ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) are members of a subfamily of related cytokines that share gp130 as common signal-transducing receptor component. CNTF has recently been demonstrated...
16.
Sonneveld E, van den Brink C, Van Der Leede B, Maden M, van der Saag P
Exp Cell Res
. 1999 Jul;
250(2):284-97.
PMID: 10413584
Embryonal carcinoma cell lines (F9 EC and P19 EC) were stably transfected with 1.8 kb promoter sequence of RARbeta2 coupled to the lacZ gene as a system for measuring active...
17.
van Schothorst E, Mohkamsing S, Van Gurp R, Oosterhuis J, van der Saag P, Looijenga L
Br J Cancer
. 1999 Jul;
80(10):1571-4.
PMID: 10408400
Aberrations within Bcl10, a gene involved in execution of apoptosis, has most recently been found in a variety of cancers, including cell lines of testicular germ cell tumours of adolescents...
18.
de Roos K, Sonneveld E, Compaan B, Ten Berge D, Durston A, van der Saag P
Mech Dev
. 1999 Jun;
82(1-2):205-11.
PMID: 10354487
Retinoids are important signal molecules during vertebrate embryonic development and their synthesis as well as catabolism should therefore be strictly regulated. The retinoic acid (RA) 4-hydroxylase, belonging to the cytochrome...
19.
Legler J, van den Brink C, Brouwer A, Murk A, van der Saag P, Vethaak A, et al.
Toxicol Sci
. 1999 May;
48(1):55-66.
PMID: 10330684
Development of an estrogen receptor-mediated, chemical-activated luciferase reporter gene-expression (ER-CALUX) assay was attempted by stable transfection of luciferase reporter genes in a number of cell lines. Stable transfection of the...
20.
Lemmen J, Broekhof J, Kuiper G, Gustafsson J, van der Saag P, van der Burg B
Mech Dev
. 1999 May;
81(1-2):163-7.
PMID: 10330493
In adult mammals numerous target tissues and organs for estrogens exist. Little is known about possible target organs during embryogenesis other than the reproductive tract and the gonads. This is...