P Marichal
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Explore the profile of P Marichal including associated specialties, affiliations and a list of published articles.
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30
Citations
720
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Recent Articles
1.
Saha A, Liu L, Marichal P, Odds F
Bioorg Med Chem Lett
. 2001 Jan;
10(24):2735-9.
PMID: 11133080
The in vitro activity of novel 4-substituted imidazole antifungals was optimized by solid-phase chemistry and parallel synthesis. Potent yeast-selective as well as broad-spectrum antifungal compounds (32 and 20) were discovered.
2.
Saha A, Liu L, Simoneaux R, Kukla M, Marichal P, Odds F
Bioorg Med Chem Lett
. 2000 Sep;
10(19):2175-8.
PMID: 11012023
A series of 4-substituted imidazole sulfonamides has been prepared by solid-phase chemistry. These compounds were found to have good in vitro antifungal activity and constitute the first examples of C-linked...
3.
Marichal P, Gorrens J, Laurijssens L, Vermuyten K, Van Hove C, Le Jeune L, et al.
Antimicrob Agents Chemother
. 1999 Oct;
43(11):2663-70.
PMID: 10543744
The effects of itraconazole on ergosterol biosynthesis were investigated in a series of 16 matched clinical Candida albicans isolates which had been previously analyzed for mechanisms of resistance to azoles...
4.
Maesaki S, Marichal P, Vanden Bossche H, Sanglard D, Kohno S
J Antimicrob Chemother
. 1999 Aug;
44(1):27-31.
PMID: 10459807
We investigated the drug efflux mechanism in azole-resistant strains of Candida albicans using rhodamine 6G (R6G). No significant differences in R6G uptake were observed between azole-sensitive B2630 (9.02 +/- 0.02...
5.
Maesaki S, Marichal P, Hossain M, Sanglard D, Vanden Bossche H, Kohno S
J Antimicrob Chemother
. 1999 Mar;
42(6):747-53.
PMID: 10052898
We investigated the effects of combining tacrolimus and azole antifungal agents in azole-resistant strains of Candida albicans by comparing the accumulation of [3H]itraconazole. The CDR1-expressing resistant strain C26 accumulated less...
6.
Marichal P, Vanden Bossche H, Odds F, Nobels G, Warnock D, Timmerman V, et al.
Antimicrob Agents Chemother
. 1997 Oct;
41(10):2229-37.
PMID: 9333053
Two isolates of Candida glabrata, one susceptible and one resistant to azole antifungals, were previously shown to differ in quantity and activity of the cytochrome P-450 14alpha-lanosterol demethylase which is...
7.
Wheat J, Marichal P, Vanden Bossche H, Le Monte A, Connolly P
Antimicrob Agents Chemother
. 1997 Feb;
41(2):410-4.
PMID: 9021199
An AIDS patient with disseminated histoplasmosis who improved during treatment with fluconazole but remained fungemic and subsequently relapsed is described. Isolates obtained from blood during therapy showed a progressive increase...
8.
Van Krunckelsven L, Marichal P, HUBENS A
Eur J Vasc Endovasc Surg
. 1995 Aug;
10(2):256-7.
PMID: 7655984
No abstract available.
9.
Marichal P, Gorrens J, Coene M, Le Jeune L, Vanden Bossche H
Mycoses
. 1995 Mar;
38(3-4):111-7.
PMID: 7477085
Two Candida krusei isolates were used to compare the effects of fluconazole, ketoconazole and itraconazole on growth and ergosterol synthesis, and to measure intracellular drug contents. Fifty per cent inhibition...
10.
Marichal P, Vanden Bossche H
Acta Biochim Pol
. 1995 Jan;
42(4):509-16.
PMID: 8852341
Until the late eighties, clinical resistance to azole antifungals was a rare phenomenon. Only a few cases of resistance to ketoconazole were found in patients with chronic mucocutaneous candidiasis (CMC)....