P M Vertino
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Explore the profile of P M Vertino including associated specialties, affiliations and a list of published articles.
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21
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1344
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Recent Articles
1.
Kennedy E, Powell D, Li Z, Bell J, Barwick B, Feng H, et al.
Sci Rep
. 2018 May;
8(1):6709.
PMID: 29712937
Human deep space and planetary travel is limited by uncertainties regarding the health risks associated with exposure to galactic cosmic radiation (GCR), and in particular the high linear energy transfer...
2.
Sharma D, Saxena N, Vertino P, Anania F
Endocr Relat Cancer
. 2006 May;
13(2):629-40.
PMID: 16728588
An increase in the risk of cancer is one of the consequences of obesity. The predominant cancers associated with obesity have a hormonal basis and include breast, prostate, endometrium, colon...
3.
Parsons M, Vertino P
Oncogene
. 2006 May;
25(52):6948-58.
PMID: 16715133
Aberrant DNA methylation of promoter region CpG islands is associated with gene silencing and serves as an alternative to mutations in the inactivation of tumor suppressor genes in human cancers....
4.
McConnell B, Vertino P
Apoptosis
. 2004 Jan;
9(1):5-18.
PMID: 14739594
TMS1/ASC is a bipartite protein comprising two protein-protein interaction domains, a pyrin domain (PYD) and a caspase recruitment domain (CARD). Proteins containing these domains play pivotal roles in regulating apoptosis...
5.
Feltus F, Lee E, Costello J, Plass C, Vertino P
Proc Natl Acad Sci U S A
. 2003 Oct;
100(21):12253-8.
PMID: 14519846
Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of CpG island methylation indicates...
6.
Marfatia K, Harreman M, Fanara P, Vertino P, Corbett A
Gene
. 2001 Apr;
266(1-2):45-56.
PMID: 11290418
Many of the proteins that mediate transport into and out of the nucleus have been structurally and functionally conserved throughout evolution. Here we describe the sequence and characterization of the...
7.
McConnell B, Vertino P
Cancer Res
. 2000 Dec;
60(22):6243-7.
PMID: 11103777
Genetic and epigenetic alterations affecting proteins involved in apoptosis can contribute to the establishment and progression of cancer. Recently, our laboratory has isolated a novel gene, TMS1, that is aberrantly...
8.
Conway K, McConnell B, Bowring C, Donald C, Warren S, Vertino P
Cancer Res
. 2000 Dec;
60(22):6236-42.
PMID: 11103776
Gene silencing associated with aberrant methylation of promoter region CpG islands is an acquired epigenetic alteration that serves as an alternative to genetic defects in the inactivation of tumor suppressor...
9.
FERGUSON A, Vertino P, Spitzner J, Baylin S, Muller M, Davidson N
J Biol Chem
. 1998 Jan;
272(51):32260-6.
PMID: 9405430
The cytosine analog 5-aza-2'-deoxycytidine is a potent inhibitor of DNA methyltransferase. Its cytotoxicity has been attributed to several possible mechanisms including reexpression of growth suppressor genes and formation of covalent...
10.
Baylin S, Herman J, Graff J, Vertino P, Issa J
Adv Cancer Res
. 1997 Oct;
72:141-96.
PMID: 9338076
Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) activity. Each component of this "methylation imbalance" may fundamentally contribute to tumor progression. The...