J P Issa
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Explore the profile of J P Issa including associated specialties, affiliations and a list of published articles.
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52
Citations
6134
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Recent Articles
1.
Plimack E, Desai J, Issa J, Jelinek J, Sharma P, Vence L, et al.
Invest New Drugs
. 2014 May;
32(5):969-75.
PMID: 24875133
Background: Melanoma cell lines treated with decitabine show upregulation of cancer antigens, and interferon-α upregulates MHC Class I antigens in cancer cells, leading to enhanced T-cell recognition and T-cell mediated...
2.
Colella S, Shen L, Baggerly K, Issa J, Krahe R
Biotechniques
. 2003 Jul;
35(1):146-50.
PMID: 12866414
No abstract available.
3.
Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma
Ueki T, Toyota M, Skinner H, Walter K, Yeo C, Issa J, et al.
Cancer Res
. 2001 Dec;
61(23):8540-6.
PMID: 11731440
To identify CpG islands differentially methylated in pancreatic adenocarcinoma, we used methylated CpG island amplification (MCA) coupled with representational difference analysis. Of 42 CpG islands identified by MCA/representational difference analysis,...
4.
Anderson G, Brenner B, Swede H, Chen N, Henry W, Conroy J, et al.
Cancer Res
. 2001 Nov;
61(22):8274-83.
PMID: 11719460
We have used genome-wide allelotyping with 348 polymorphic autosomal markers spaced, on average, 10 cM apart to quantitate the extent of intrachromosomal instability in 59 human sporadic colorectal carcinomas. We...
5.
Peng H, Shen N, Qian L, Sun X, Koduru P, Goodwin L, et al.
Br J Cancer
. 2001 Sep;
85(6):930-5.
PMID: 11556848
We have sequenced the promoter region of the murine asparagine synthetase gene and examined its methylation profile in the CpG islands of L-asparaginase-sensitive 6C3HED cells (asparagine auxotrophs) and resistant variants...
6.
Rashid A, Shen L, Morris J, Issa J, Hamilton S
Am J Pathol
. 2001 Sep;
159(3):1129-35.
PMID: 11549606
Methylation of cytosines in CpG islands silences gene expression. CpG island methylator phenotype (CIMP) in colorectal cancers is characterized by abnormal methylation of multiple CpG islands including those in several...
7.
Luo R, Peng H, Xu F, Bao J, Pang Y, Pershad R, et al.
Biochim Biophys Acta
. 2001 Jun;
1519(3):216-22.
PMID: 11418188
We have recently identified a maternally imprinted tumor suppressor gene, ARHI (aplysia ras homolog I), the expression of which is lost in ovarian and breast cancers. We have now characterized...
8.
Issa J, Ahuja N, Toyota M, Bronner M, Brentnall T
Cancer Res
. 2001 Apr;
61(9):3573-7.
PMID: 11325821
CpG island hypermethylation is a mechanism of gene silencing that can be usurped by neoplastic cells to inactivate undesirable genes. In the colon, hypermethylation often starts in normal mucosa as...
9.
Toyota M, Kopecky K, Toyota M, Jair K, Willman C, Issa J
Blood
. 2001 Apr;
97(9):2823-9.
PMID: 11313277
Aberrant methylation of multiple CpG islands has been described in acute myeloid leukemia (AML), but it is not known whether these are independent events or whether they reflect specific methylation...
10.
Santini V, Kantarjian H, Issa J
Ann Intern Med
. 2001 Apr;
134(7):573-86.
PMID: 11281740
Methylation of DNA is a biochemical modification that can influence gene expression and is involved in inactivating one of the two X chromosomes in women. Evidence that has accumulated in...