P J Vickers
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Explore the profile of P J Vickers including associated specialties, affiliations and a list of published articles.
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35
Citations
849
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Recent Articles
1.
Borazanci E, Schram A, Garralda E, Brana I, Vieito Villar M, Spreafico A, et al.
ESMO Open
. 2022 Aug;
7(4):100530.
PMID: 35921760
Background: Activation of leukemia inhibitory factor (LIF) is linked to an immunosuppressive tumor microenvironment (TME), with a strong association between LIF expression and tumor-associated macrophages (TAMs). MSC-1 (AZD0171) is a...
2.
Kilty I, Vickers P
Clin Exp Allergy
. 1999 Dec;
29(12):1671-80.
PMID: 10594544
Background: Influx of eosinophils into the post-capillary bronchial epithelium and the subsequent release of inflammatory mediators is characteristic of the late phase of asthmatic attacks. The genes that serve to...
3.
Kilty I, Logan A, Vickers P
Eur J Biochem
. 1999 Oct;
266(1):83-93.
PMID: 10542053
The lipoxygenases (LOs) are a family of nonheme iron dioxygenases that catalyse the insertion of molecular oxygen into polyunsaturated fatty acids. Five members of this gene family have been described...
4.
Wong E, DeLuca C, Boily C, Charleson S, Cromlish W, Denis D, et al.
Inflamm Res
. 1997 Feb;
46(2):51-9.
PMID: 9085144
The human osteosarcoma 143.98.2 cell line was found to express high levels of prostaglandin synthase-2 (PGHS-2) without detectable levels of prostaglandin synthase-1 (PGHS-1) as measured by reverse transcriptase-polymerase chain reaction...
5.
Vickers P, DeLuca C, Wong E, Abramovitz M
Adv Exp Med Biol
. 1997 Jan;
400A:145-51.
PMID: 9547550
No abstract available.
6.
Mancini J, Vickers P, ONeill G, Boily C, Falgueyret J, Riendeau D
Mol Pharmacol
. 1997 Jan;
51(1):52-60.
PMID: 9016346
Aspirin (ASA) acetylates Ser516 of prostaglandin G/H synthase-2 (PGHS-2) resulting in a modified enzyme that converts arachidonic acid to 15(R)-hydroxy-eicosatetraeroic acid [15(R)-HETE]. ASA has pharmacological benefits that may not all...
7.
Mancini J, Riendeau D, Falgueyret J, Vickers P, ONeill G
J Biol Chem
. 1995 Dec;
270(49):29372-7.
PMID: 7493972
The therapeutic action of nonsteroidal anti-inflammatory drugs (NSAIDs) is exerted through the inhibition of prostaglandin G/H synthase (PGHS), which is expressed as two isoenzymes, termed PGHS-1 and PGHS-2. From the...
8.
Vickers P
J Lipid Mediat Cell Signal
. 1995 Oct;
12(2-3):185-94.
PMID: 8777565
No abstract available.
9.
Vickers P, Wittig U, Lehmann W, Stark H, Fusenig N, Rosenbach T, et al.
Proc Natl Acad Sci U S A
. 1995 Jul;
92(15):6966-70.
PMID: 7624354
We studied the expression of arachidonate 5-lipoxygenase (5-LO) in a cell line of human keratinocytes (HaCaT) and in normal human skin keratinocytes in tissue culture. In undifferentiated keratinocytes 5-LO gene...
10.
Kargman S, ONeill G, Vickers P, Evans J, Mancini J, Jothy S
Cancer Res
. 1995 Jun;
55(12):2556-9.
PMID: 7780968
Prostaglandin G/H synthase (PGHS), a key enzyme leading to the formation of prostaglandins, is the target of nonsteroidal antiinflammatory drugs. Two forms of the enzyme have been identified, PGHS-1 and...