G P ONeill
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Explore the profile of G P ONeill including associated specialties, affiliations and a list of published articles.
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47
Citations
1504
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Recent Articles
1.
Gervais F, Cruz R, Chateauneuf A, Gale S, Sawyer N, Nantel F, et al.
J Allergy Clin Immunol
. 2001 Dec;
108(6):982-8.
PMID: 11742277
Background: PGD(2) is the major prostanoid released by mast cells during an allergic response. Its role in the allergic response, however, remains unclear. Objective: Because the accumulation of eosinophils is...
2.
Bertrand S, Ng G, Purisai M, Wolfe S, Severidt M, Nouel D, et al.
J Pharmacol Exp Ther
. 2001 Jun;
298(1):15-24.
PMID: 11408520
Gabapentin (Neurontin, Pfizer Global R & D) is a novel anticonvulsant, antihyperalgesic, and antinociceptive agent with a poorly understood mechanism of action. In this study, we show that gabapentin (EC50...
3.
Figueroa D, Breyer R, Defoe S, Kargman S, Daugherty B, Waldburger K, et al.
Am J Respir Crit Care Med
. 2001 Feb;
163(1):226-33.
PMID: 11208650
The cysteinyl leukotrienes (CysLTs) are important mediators of human asthma. Pharmacologic and clinical studies show that the CysLTs exert most of their bronchoconstrictive and proinflammatory effects through activation of a...
4.
Ng G, Bertrand S, Sullivan R, Ethier N, Wang J, Yergey J, et al.
Mol Pharmacol
. 2000 Dec;
59(1):144-52.
PMID: 11125035
Gamma-aminobutyric acid (GABA) activates two qualitatively different inhibitory mechanisms through ionotropic GABA(A) multisubunit chloride channel receptors and metabotropic GABA(B) G protein-coupled receptors. Evidence suggests that pharmacologically distinct GABA(B) receptor subtypes...
5.
Heise C, ODowd B, Figueroa D, Sawyer N, Nguyen T, Im D, et al.
J Biol Chem
. 2000 Jun;
275(39):30531-6.
PMID: 10851239
The contractile and inflammatory actions of the cysteinyl leukotrienes (CysLTs), LTC(4), LTD(4), and LTE(4), are thought to be mediated through at least two distinct but related CysLT G protein-coupled receptors....
6.
Sullivan R, Chateauneuf A, Coulombe N, Kolakowski Jr L, Johnson M, Hebert T, et al.
J Pharmacol Exp Ther
. 2000 Apr;
293(2):460-7.
PMID: 10773016
Direct evidence is lacking to show whether the gamma-aminobutyric acid (GABA)(B) gb1-gb2 heterodimer is the signaling form of the receptor. In this study, we tested whether gb1a or gb2 subunits...
7.
Boie Y, Stocco R, Sawyer N, Greig G, Kargman S, Slipetz D, et al.
Eur J Pharmacol
. 1999 Oct;
380(2-3):203-13.
PMID: 10513580
A cDNA clone coding for the guinea pig leukotriene B4 (BLT) receptor has been isolated from a lung cDNA library. The guinea pig BLT receptor has an open reading frame...
8.
Chan C, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, et al.
J Pharmacol Exp Ther
. 1999 Jul;
290(2):551-60.
PMID: 10411562
The discoveries that cyclooxygenase (COX)-2 is an inducible form of COX involved in inflammation and that COX-1 is the major isoform responsible for the production of prostaglandins (PGs) in the...
9.
Prasit P, Wang Z, Brideau C, Chan C, Charleson S, Cromlish W, et al.
Bioorg Med Chem Lett
. 1999 Jul;
9(13):1773-8.
PMID: 10406640
The development of a COX-2 inhibitor rofecoxib (MK 966, Vioxx) is described. It is essentially equipotent to indomethacin both in vitro and in vivo but without the ulcerogenic side effect...
10.
Lynch K, ONeill G, Liu Q, Im D, Sawyer N, Metters K, et al.
Nature
. 1999 Jul;
399(6738):789-93.
PMID: 10391245
The cysteinyl leukotrienes-leukotriene C4(LTC4), leukotriene D4(LTD4) and leukotriene E4(LTE4)-are important mediators of human bronchial asthma. Pharmacological studies have determined that cysteinyl leukotrienes activate at least two receptors, designated CysLT1 and...