P J Tummino
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Explore the profile of P J Tummino including associated specialties, affiliations and a list of published articles.
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23
Citations
889
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Recent Articles
11.
Tummino P, Harvey P, McQuade T, Domagala J, Gogliotti R, Sanchez J, et al.
Antimicrob Agents Chemother
. 1997 Feb;
41(2):394-400.
PMID: 9021197
It has been shown previously by our group and others that a series of four disulfide benzamides with cellular anti-human immunodeficiency virus (HIV) activity can eject zinc from HIV type...
12.
Tummino P, Prasad J, Ferguson D, Nouhan C, Graham N, Domagala J, et al.
Bioorg Med Chem
. 1996 Sep;
4(9):1401-10.
PMID: 8894098
Several small, achiral nonpeptide inhibitors of HIV-1 protease with low micromolar activity were identified by mass screening of the Parke-Davis compound library. Two of the compounds, structurally similar, were both...
13.
Vara Prasad J, Tummino P, Ferguson D, Saunders J, Vander Roest S, McQuade T, et al.
Biochem Biophys Res Commun
. 1996 Apr;
221(3):815-20.
PMID: 8630044
A systematic study of tethering various groups on 6-phenyl ring of 4-hydroxy-6-phenyl-3-[(2-isopropylphenyl)thio]pyran-2-one was performed to increase the binding affinity with HIV protease. This tethering approach was aimed to fill S3...
14.
Prasad J, Lunney E, Para K, Tummino P, Ferguson D, Hupe D, et al.
Drug Des Discov
. 1996 Apr;
13(3-4):15-28.
PMID: 8874041
From an initial mass screening lead, (IC50: 3 microM) and information derived from the X-ray crystallographic structure of a related analog, complexed with HIV protease (PR), the design of more...
15.
Tait B, Domagala J, Ellsworth E, Ferguson D, Gajda C, Hupe D, et al.
J Mol Recognit
. 1996 Mar;
9(2):139-42.
PMID: 8877805
New templates were designed and prepared which straddle the active site of HIV-1 protease. These templates were designed to be "flexible scaffolds' upon which substituents could be appended to fill...
16.
Tummino P, Scholten J, Harvey P, Holler T, Maloney L, Gogliotti R, et al.
Proc Natl Acad Sci U S A
. 1996 Feb;
93(3):969-73.
PMID: 8577770
Several disulfide benzamides have been shown to possess wide-spectrum antiretroviral activity in cell culture at low micromolar to submicromolar concentrations, inhibiting human immunodeficiency virus (HIV) type 1 (HIV-1) clinical and...
17.
Prasad J, Para K, Tummino P, Ferguson D, McQuade T, Lunney E, et al.
J Med Chem
. 1995 Mar;
38(6):898-905.
PMID: 7699705
Using molecular modeling and the information derived from the X-ray crystal structure of HIV-1 protease (HIV PR) complexed with the pyran-2-one 1, a series of (4-hydroxy-6-phenyl-2-oxo-2H-pyran-3-yl)thiomethanes was designed and analyzed...
18.
Tummino P, Ferguson D, Jacobs C, Tait B, Hupe L, Lunney E, et al.
Arch Biochem Biophys
. 1995 Jan;
316(1):523-8.
PMID: 7840661
A novel series of nonpeptidic compounds that contain a biphenyl carboxylic acid group have been shown to inhibit HIV-1 protease. The active compounds, most of which are highly soluble, have...
19.
Tummino P, Ferguson D, Hupe D
Biochem Biophys Res Commun
. 1994 May;
201(1):290-4.
PMID: 8198586
The oral anticoagulant warfarin (4-hydroxy-3-(3-oxo-1-phenylbutyl)- benzopyran-2-one) is a structurally novel low micromolar competitive inhibitor of HIV-1 protease in vitro. It was recently reported that warfarin inhibits HIV-1 infection in U-1...
20.
Tummino P, Ferguson D, Hupe L, Hupe D
Biochem Biophys Res Commun
. 1994 May;
200(3):1658-64.
PMID: 8185622
The nonpeptide compounds C1 (4-hydroxy-3-(3-phenoxypropyl)-1-benzopyran-2-one) and P1 (4-hydroxy-6-phenyl-3-(phenylthio)pyran-2-one) are structurally novel low micromolar inhibitors of the protease of human immunodeficiency virus type 1 (HIV-1). Kinetic analysis revealed that both compounds...