P J Tummino
Overview
Explore the profile of P J Tummino including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
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Articles
23
Citations
889
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0
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Recent Articles
1.
Kumar R, Crouthamel M, Rominger D, Gontarek R, Tummino P, Levin R, et al.
Br J Cancer
. 2009 Oct;
101(10):1717-23.
PMID: 19844230
Background: Myelosuppression has been observed with several multikinase angiogenesis inhibitors in clinical studies, although the frequency and severity varies among the different agents. Inhibitors targeting vascular endothelial growth factor receptor...
2.
Boyer F, Vara Prasad J, Domagala J, Ellsworth E, Gajda C, Hagen S, et al.
J Med Chem
. 2000 Mar;
43(5):843-58.
PMID: 10715152
On the basis of previous SAR findings and molecular modeling studies, a series of compounds were synthesized which possessed various sulfonyl moieties substituted at the 4-position of the C-3 phenyl...
3.
Prasad J, Boyer F, Domagala J, Ellsworth E, Gajda C, Hamilton H, et al.
Bioorg Med Chem
. 2000 Feb;
7(12):2775-800.
PMID: 10658583
With the insight generated by the availability of X-ray crystal structures of various 5,6-dihydropyran-2-ones bound to HIV PR, inhibitors possessing various alkyl groups at the 6-position of 5,6-dihydropyran-2-one ring were...
4.
Vara Prasad J, Markoski L, Boyer F, Domagala J, Ellsworth E, Gajda C, et al.
Bioorg Med Chem Lett
. 1999 Aug;
9(15):2217-22.
PMID: 10465549
Dihydropyran-2-ones possessing a sulfamate moiety at the 4-position of the thiophenyl ring were designed to reach S3' pocket of the HIV protease. Synthetic routes for the preparation of thiotosylates possessing...
5.
Ellsworth E, Domagala J, Prasad J, Hagen S, Ferguson D, Holler T, et al.
Bioorg Med Chem Lett
. 1999 Aug;
9(14):2019-24.
PMID: 10450973
5,6-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease, which bind to the S1, S2, S1', and S2' pockets and have a unique binding mode with the catalytic aspartyl groups and the...
6.
Vara Prasad J, Boyer F, Domagala J, Ellsworth E, Gajda C, Hagen S, et al.
Bioorg Med Chem Lett
. 1999 Jul;
9(11):1481-6.
PMID: 10386921
Dihydropyran-2-ones possessing amino and carboxamide functionalities on 3-SPh (2-tert-butyl, 5-methyl) ring were synthesized and evaluated for their antiviral activities. Both the enantiomers of inhibitor 15 were synthesized. The in vitro...
7.
Alm R, Ling L, Moir D, King B, Brown E, Doig P, et al.
Nature
. 1999 Jan;
397(6715):176-80.
PMID: 9923682
Helicobacter pylori, one of the most common bacterial pathogens of humans, colonizes the gastric mucosa, where it appears to persist throughout the host's life unless the patient is treated. Colonization...
8.
Tait B, Hagen S, Domagala J, Ellsworth E, Gajda C, Hamilton H, et al.
J Med Chem
. 1997 Nov;
40(23):3781-92.
PMID: 9371244
The 4-hydroxy-5,6-dihydropyrone template was utilized as a flexible scaffolding from which to build potent active site inhibitors of HIV protease. Dihydropyrone 1c (5,6-dihydro-4-hydroxy-6-phenyl-3-[(2-phenylethyl)thio]-2H-pyran-2-one) was modeled in the active site of...
9.
Hagen S, Prasad J, Boyer F, Domagala J, Ellsworth E, Gajda C, et al.
J Med Chem
. 1997 Nov;
40(23):3707-11.
PMID: 9371233
No abstract available.
10.
Domagala J, BADER J, Gogliotti R, Sanchez J, Stier M, Song Y, et al.
Bioorg Med Chem
. 1997 Mar;
5(3):569-79.
PMID: 9113335
As part of the National Cancer Institute's Drug Screening Program, a new class of antiretrovirals active against the human immunodeficiency virus HIV-1 has been identified, and the HIV-1 nucleocapsid protein...