P J Sims
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Explore the profile of P J Sims including associated specialties, affiliations and a list of published articles.
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91
Citations
2793
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Recent Articles
1.
Huang Y, Zhao Q, Zhou C, Gu Z, Li D, Xu H, et al.
Oncogene
. 2006 May;
25(50):6618-27.
PMID: 16702944
Phospholipid scramblase 1 (PLSCR1) is a multiply palmitoylated protein which is localized in either the cell membrane or nucleus depending on its palmitoylated state. The increasing evidence showed the biological...
2.
de Vries K, Wiedmer T, Sims P, Gadella B
Biol Reprod
. 2003 Feb;
68(6):2122-34.
PMID: 12606386
Only capacitated sperm cells are able to fertilize egg cells, and this process is triggered by high levels of bicarbonate. Bicarbonate renders the plasma membrane more fluid, which is caused...
3.
Sims P, Wiedmer T
Thromb Haemost
. 2001 Aug;
86(1):266-75.
PMID: 11487015
Plasma membrane phospholipid asymmetry is maintained by an aminophospholipid translocase that transports phosphatidylserine (PS) and phosphatidylethanolamine (PE) from outer to inner membrane leaflet. Cell activation or injury leads to redistribution...
4.
Sun J, Zhao J, Schwartz M, Wang J, Wiedmer T, Sims P
J Biol Chem
. 2001 Jun;
276(31):28984-90.
PMID: 11390389
Phospholipid scramblase 1 (PLSCR1) is a plasma membrane protein that has been proposed to play a role in the transbilayer movement of plasma membrane phospholipids. PLSCR1 contains multiple proline-rich motifs...
5.
Zhou Q, Zhao J, Al-Zoghaibi F, Zhou A, Wiedmer T, Silverman R, et al.
Blood
. 2001 Feb;
95(8):2593-9.
PMID: 10753839
Interferons (IFNs) mediate their diverse biologic activities through induction of the expression of multiple genes. Whereas the mode of action of certain of these IFN-regulated genes has been well characterized,...
6.
Wiedmer T, Zhou Q, Kwoh D, Sims P
Biochim Biophys Acta
. 2000 Aug;
1467(1):244-53.
PMID: 10930526
Phospholipid (PL) scramblase is a 35 kDa protein that is thought to mediate Ca2+-induced bidirectional transbilayer movement of plasma membrane phospholipids in activated, injured, or apoptotic cells. We recently reported...
7.
Tepper A, Ruurs P, Wiedmer T, Sims P, Borst J, van Blitterswijk W
J Cell Biol
. 2000 Jul;
150(1):155-64.
PMID: 10893264
Apoptosis is generally accompanied by a late phase of ceramide (Cer) production, the significance of which is unknown. This study describes a previously unrecognized link between Cer accumulation and phosphatidylserine...
8.
Fadeel B, Gleiss B, Hogstrand K, Chandra J, Wiedmer T, Sims P, et al.
Biochem Biophys Res Commun
. 1999 Dec;
266(2):504-11.
PMID: 10600532
Phosphatidylserine (PS) exposure on the surface of cells has been considered a characteristic feature of apoptosis. However, we demonstrate herein that externalization of PS occurs in a cell-type-specific, albeit caspase-dependent,...
9.
Simon C, Sims P, Elston D
Cutis
. 1999 Jul;
63(6):341-3.
PMID: 10388956
Cutaneous squamous cell carcinomas may cause death by metastasis or by local extension. We describe a deeply invasive cutaneous squamous cell carcinoma that caused death by direct extension into the...
10.
Wilson H, Waldrip J, Nielson K, Judd A, Han S, Cho W, et al.
J Biol Chem
. 1999 Apr;
274(17):11494-504.
PMID: 10206954
Exposure of S49 lymphoma cells to exogenous group IIA or V secretory phospholipase A2 (sPLA2) caused an initial release of fatty acid followed by resistance to further hydrolysis by the...