P H Schlesinger
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Explore the profile of P H Schlesinger including associated specialties, affiliations and a list of published articles.
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2563
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Recent Articles
11.
Schaible U, Schlesinger P, Russell D
J Immunol
. 1998 May;
160(3):1290-6.
PMID: 9570546
Mycobacterium avium (MAC) organisms multiply in phagosomes that have restricted fusigenicity with lysosomes, do not acidify due to a paucity of vacuolar proton-ATPases, yet remain accessible to recycling endosomes. During...
12.
Schlesinger P, Gross A, Yin X, Yamamoto K, Saito M, Waksman G, et al.
Proc Natl Acad Sci U S A
. 1997 Oct;
94(21):11357-62.
PMID: 9326614
The BCL-2 family of proteins is composed of both pro- and antiapoptotic regulators, although its most critical biochemical functions remain uncertain. The structural similarity between the BCL-XL monomer and several...
13.
Schlesinger P, Blair H, Teitelbaum S, Edwards J
J Biol Chem
. 1997 Jul;
272(30):18636-43.
PMID: 9228032
Bone resorption by osteoclasts requires massive transcellular acid transport, which is accomplished by the parallel action of a V-type proton pump and a chloride channel in the osteoclast ruffled border....
14.
Desai S, McCleskey E, Schlesinger P, Krogstad D
Am J Trop Med Hyg
. 1996 May;
54(5):464-70.
PMID: 8644899
Growth of the human malaria parasite, Plasmodium falciparum, within the red blood cell (RBC) requires external Ca++ and is associated with a markedly elevated intracellular Ca++ concentration, [Ca++]i. We used...
15.
Dong S, Stransky G, Whitaker C, Jordan S, Schlesinger P, Edwards J, et al.
Biochim Biophys Acta
. 1995 Aug;
1251(1):69-73.
PMID: 7647095
Overlapping cDNA fragments encoding avian cathepsin B were cloned from an osteoclast cDNA library and sequenced. The primary structure of the prepro enzyme deduced from this sequence has 340 amino...
16.
Mattsson J, Schlesinger P, Keeling D, Teitelbaum S, Stone D, Xie X
J Biol Chem
. 1994 Oct;
269(40):24979-82.
PMID: 7929181
A vacuolar-type proton-translocating ATPase was extracted from ruffled membranes of chicken osteoclasts with 1% polyoxyethylene 9-lauryl ether (C12E9) and was purified 13-fold by glycerol gradient centrifugation. The isolated pump appears...
17.
Schlesinger P, Chakraborty P, Haddix P, Collins H, Fok A, Allen R, et al.
Science
. 1994 Feb;
263(5147):678-81.
PMID: 8303277
The success of Mycobacterium species as pathogens depends on their ability to maintain an infection inside the phagocytic vacuole of the macrophage. Although the bacteria are reported to modulate maturation...
18.
Schlesinger P, Mattsson J, Blair H
Miner Electrolyte Metab
. 1994 Jan;
20(1-2):31-9.
PMID: 8202050
In order to solubilize bone mineral and degrade the organic matrix of bone osteoclasts must secrete 1-2 protons for every Ca2+ liberated. This transport is a major metabolic activity of...
19.
20.
Blair H, Schlesinger P, Ross F, Teitelbaum S
Clin Orthop Relat Res
. 1993 Sep;
(294):7-22.
PMID: 8395372
Osteoclasts develop from precursor cells of the monocyte series. However, specialized differentiation for efficient bone degradation separates the osteoclast from the macrophage. The physical reasons for these differences are emerging...