P H Beaune
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Explore the profile of P H Beaune including associated specialties, affiliations and a list of published articles.
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51
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Recent Articles
1.
Gervot L, Carriere V, Costet P, Cugnenc P, Berger A, Beaune P, et al.
Environ Toxicol Pharmacol
. 2011 Jul;
2(4):381-8.
PMID: 21781746
CYP3A is known to be expressed in liver, small intestine and colon. However, its isoform distribution (CYP3A4, 3A5 and 3A7) and inducibility have not been clearly elucidated in the colon....
2.
Lakehal F, Dansette P, Becquemont L, Lasnier E, Delelo R, Balladur P, et al.
Chem Res Toxicol
. 2001 Jun;
14(6):694-701.
PMID: 11409940
Flucloxacillin, an isoxazolyl-penicillin, causes cholestasis and biliary epithelium injury. The aim of the study was to determine whether flucloxacillin, either directly or through metabolite formation, may induce cytotoxicity in hepatic...
3.
Morin S, Loriot M, Poirier J, Tenneze L, Beaune P, Funck-Brentano C, et al.
Eur J Clin Pharmacol
. 2001 Apr;
56(11):793-7.
PMID: 11294368
Introduction: Besides the low therapeutic index drug tolbutamide, there is no validated in vivo probe to assess the genetically determined CYP2C9 activity in humans. The in vitro CYP2C9-specific substrate diclofenac...
4.
Thijssen H, Flinois J, Beaune P
Drug Metab Dispos
. 2000 Oct;
28(11):1284-90.
PMID: 11038154
The oral anticoagulant acenocoumarol is given as a racemic mixture. The (S)-enantiomer is rapidly cleared and is the reason why only (R)-acenocoumarol contributes to the pharmacological effect. The objective of...
5.
Lakehal F, Wendum D, Barbu V, Becquemont L, Poupon R, Balladur P, et al.
Hepatology
. 1999 Nov;
30(6):1498-506.
PMID: 10573530
Tissue expression of drug-metabolizing enzymes influences susceptibility to drugs and carcinogens. Because the biliary epithelium, exposed to bile-borne chemicals, may give rise to drug-induced cholangiopathies and to cholangiocarcinomas, we determined...
6.
Dansette P, Bonierbale E, Minoletti C, Beaune P, Pessayre D, Mansuy D
Eur J Drug Metab Pharmacokinet
. 1999 May;
23(4):443-51.
PMID: 10323325
Immune-related drug responses are one of the most common sources of idiosyncratic toxicity. A number of organs may be the target of such reactions; however, this review concentrates mostly on...
7.
Louerat-Oriou B, Flinois J, Beaune P, Pompon D
Pharmacogenetics
. 1999 Apr;
9(1):61-70.
PMID: 10208644
P450 S12, an engineered human P450 1A2 containing the 88-first amino-acids of the P450 1A1, demonstrates particularly high expression level in yeast while exhibiting catalytic properties very similar to the...
8.
Gauffre A, Mircheva J, Glotz D, Fillastre J, Simon P, Beaune P, et al.
Nephrol Dial Transplant
. 1997 Nov;
12(9):1961-2.
PMID: 9306350
In the present study we report on four cases of acute interstitial nephritis (AIN) and two cases of hepatitis induced by quinolone. We show by immunoblotting analysis that all sera...
9.
Belloc C, Gauffre A, Andre C, Beaune P
Pharmacogenetics
. 1997 Jun;
7(3):181-6.
PMID: 9241657
Dihydralazine-induced hepatitis is characterized by the presence of anti-liver microsomal (anti-LM) autoantibodies in the sera of patients. Cytochrome P450 1A2 (CYP1A2), involved in the metabolism of dihydralazine, was shown to...
10.
Ploemen J, Wormhoudt L, Haenen G, Oudshoorn M, Commandeur J, Vermeulen N, et al.
Toxicol Appl Pharmacol
. 1997 Mar;
143(1):56-69.
PMID: 9073592
Ethylene dibromide (1,2-dibromoethane, EDB) is metabolized by two routes: a conjugative route catalyzed by glutathione S-transferases (GST) and an oxidative route catalyzed by cytochrome P450 (P450). The GST route is...