P E Fraser
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Explore the profile of P E Fraser including associated specialties, affiliations and a list of published articles.
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99
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5914
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Recent Articles
1.
Fa M, Puzzo D, Piacentini R, Staniszewski A, Zhang H, Baltrons M, et al.
Sci Rep
. 2016 Jan;
6:19393.
PMID: 26786552
Non-fibrillar soluble oligomeric forms of amyloid-β peptide (oAβ) and tau proteins are likely to play a major role in Alzheimer's disease (AD). The prevailing hypothesis on the disease etiopathogenesis is...
2.
Wijesekara N, Ahrens R, Wu L, Ha K, Liu Y, Wheeler M, et al.
Diabetes Obes Metab
. 2015 Jun;
17(10):1003-6.
PMID: 26095311
Increasing evidence points to the cytotoxicity of islet amyloid polypeptide (IAPP) aggregates as a major contributor to the loss of β-cell mass in type 2 diabetes. Prevention of IAPP formation...
3.
Potter K, Werner I, Denroche H, Montane J, Plesner A, Chen Y, et al.
Am J Transplant
. 2015 Apr;
15(6):1519-30.
PMID: 25833002
Islet transplantation is a promising therapy for patients with diabetes, but its long-term success is limited by many factors, including the formation of islet amyloid deposits. Heparin is employed in...
4.
Bohm C, Chen F, Sevalle J, Qamar S, Dodd R, Li Y, et al.
Mol Cell Neurosci
. 2015 Mar;
66(Pt A):3-11.
PMID: 25748120
Inherited variants in multiple different genes are associated with increased risk for Alzheimer's disease (AD). In many of these genes, the inherited variants alter some aspect of the production or...
5.
Allemang-Grand R, Scholz J, Ellegood J, Cahill L, Laliberte C, Fraser P, et al.
Neurobiol Aging
. 2014 Oct;
36(2):638-47.
PMID: 25311279
Murine models of Alzheimer's disease (AD) have been used to draw associations between atrophy of neural tissue and underlying pathology. In this study, the early-onset TgCRND8 mouse model of AD...
6.
Kanemoto S, Griffin J, Markham-Coultes K, Aubert I, Tandon A, George-Hyslop P, et al.
Neuroscience
. 2013 Dec;
261:52-9.
PMID: 24361736
The amyloid precursor protein (APP) and amyloid-β (Aβ) peptide play central roles in the pathology and etiology of Alzheimer's disease. Amyloid-induced impairments in neurogenesis have been investigated in several transgenic...
7.
St George-Hyslop P, Fraser P
J Neurochem
. 2011 Nov;
120 Suppl 1:84-88.
PMID: 22122073
The presenilin complex is composed of four core proteins (presenilin 1 or presenilin 2, APH1, nicastrin, and PEN2). Several endogenous proteins have been reported to selectively modulate the function of...
8.
9.
Zraika S, Hull R, Verchere C, Clark A, Potter K, Fraser P, et al.
Diabetologia
. 2010 Feb;
53(6):1046-56.
PMID: 20182863
Type 2 diabetes is a progressive disease characterised by islet amyloid deposits in the majority of patients. Amyloid formation is considered a significant factor in deterioration of islet function and...
10.
Potter K, Abedini A, Marek P, Klimek A, Butterworth S, Driscoll M, et al.
Proc Natl Acad Sci U S A
. 2010 Feb;
107(9):4305-10.
PMID: 20160085
Islet transplantation is a promising treatment for diabetes but long-term success is limited by progressive graft loss. Aggregates of the beta cell peptide islet amyloid polypeptide (IAPP) promote beta cell...