P H St George-Hyslop
Overview
Explore the profile of P H St George-Hyslop including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
75
Citations
2723
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Jun G, Ibrahim-Verbaas C, Vronskaya M, Lambert J, Chung J, Naj A, et al.
Mol Psychiatry
. 2015 Mar;
21(1):108-17.
PMID: 25778476
APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of...
2.
Bohm C, Chen F, Sevalle J, Qamar S, Dodd R, Li Y, et al.
Mol Cell Neurosci
. 2015 Mar;
66(Pt A):3-11.
PMID: 25748120
Inherited variants in multiple different genes are associated with increased risk for Alzheimer's disease (AD). In many of these genes, the inherited variants alter some aspect of the production or...
3.
Steele J, Lachenmayer M, Ju S, Stock A, Liken J, Kim S, et al.
Mol Psychiatry
. 2012 Aug;
18(8):889-97.
PMID: 22850627
Latrepirdine (Dimebon) is a pro-neurogenic, antihistaminic compound that has yielded mixed results in clinical trials of mild to moderate Alzheimer's disease, with a dramatically positive outcome in a Russian clinical...
4.
Orlacchio A, Gaudiello F, Totaro A, Floris R, St George-Hyslop P, Bernardi G, et al.
Neurology
. 2004 May;
62(10):1875-8.
PMID: 15159500
The clinical and genetic findings are described for 16 patients from a large Italian family with a variant form of hereditary spastic paraplegia and congenital arachnoid cysts inherited as an...
5.
Rogaeva E, Bergeron C, Sato C, Moliaka I, Kawarai T, Toulina A, et al.
Neurology
. 2003 Oct;
61(7):1005-7.
PMID: 14557582
PS1 mutations are associated with classic Alzheimer's disease (AD); however, some families develop AD and spastic paraplegia (SP) with brain pathology characterized by Abeta cotton wool plaques. The authors report...
6.
St George-Hyslop P, McLaurin J, Fraser P
Drug News Perspect
. 2003 Aug;
13(5):281-8.
PMID: 12937642
The molecular and cellular processes that lead to the production of the amyloid beta (A beta) peptide and some of the processes associated with A beta fibrillogenesis and neurotoxicity have...
7.
Orlacchio A, Kawarai T, Rogaeva E, Song Y, Paterson A, Bernardi G, et al.
Neurology
. 2002 Nov;
59(9):1395-401.
PMID: 12427890
Background: Seven loci for autosomal dominant hereditary spastic paraplegia (ADHSP) have been mapped. To date, two families of SPG12 (chromosome 19q13) have been analyzed; however, there is not enough clinical...
8.
Taddei K, Fisher C, Laws S, Martins G, Paton A, Clarnette R, et al.
Mol Psychiatry
. 2002 Aug;
7(7):776-81.
PMID: 12192622
Mutations in the presenilin-1 (PS-1) gene on chromosome 14 account for the majority of early-onset familial Alzheimer's disease (FAD) cases. To date, more than 90 mutations have been identified and,...
9.
Chen F, Yu G, Arawaka S, Nishimura M, Kawarai T, Yu H, et al.
Nat Cell Biol
. 2001 Aug;
3(8):751-4.
PMID: 11483961
The presenilins and nicastrin, a type 1 transmembrane glycoprotein, form high molecular weight complexes that are involved in cleaving the beta-amyloid precursor protein (betaAPP) and Notch in their transmembrane domains....
10.
Fraser P, Yu G, Levesque L, Nishimura M, Yang D, Mount H, et al.
Biochem Soc Symp
. 2001 Jul;
(67):89-100.
PMID: 11447843
Missense mutations in presenilin 1 (PS1) and presenilin 2 (PS2) are associated with early-onset familial Alzheimer's disease which displays an accelerated deposition of amyloid plaques and neurofibrillary tangles. Presenilins are...