P E Declercq
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Explore the profile of P E Declercq including associated specialties, affiliations and a list of published articles.
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34
Citations
484
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Recent Articles
1.
Baes M, Gressens P, Huyghe S, De N, Qi C, Jia Y, et al.
J Neuropathol Exp Neurol
. 2002 Apr;
61(4):368-74.
PMID: 11939592
The purpose of this study was to investigate whether deficient peroxisomal beta-oxidation is causally involved in the neuronal migration defect observed in Pex5 knockout mice. These mice are models for...
2.
BAUMGART E, Vanhorebeek I, Grabenbauer M, Borgers M, Declercq P, Fahimi H, et al.
Am J Pathol
. 2001 Oct;
159(4):1477-94.
PMID: 11583975
Zellweger syndrome (cerebro-hepato-renal syndrome) is the most severe form of the peroxisomal biogenesis disorders leading to early death of the affected children. To study the pathogenetic mechanisms causing organ dysfunctions...
3.
Vanhorebeek I, Baes M, Declercq P
Biochim Biophys Acta
. 2001 Jun;
1532(1-2):28-36.
PMID: 11420171
Because several studies indicated that peroxisomes are important for the biosynthesis of isoprenoids, we wanted to investigate whether a reduced availability of isoprenoids could be one of the pathogenic factors...
4.
van Houte H, de Hoffmann E, Van Veldhoven P, Mannaerts G, Carchon H, Baes M, et al.
Lipids
. 2001 Jun;
36(4):367-72.
PMID: 11383687
The goal of this study was to clarify the mechanism responsible for the catabolism of alpha-tocopherol. The vitamin, bound to albumin, was incubated with rat liver microsomes and appeared to...
5.
Huyghe S, Casteels M, Janssen A, Meulders L, Mannaerts G, Declercq P, et al.
Biochem J
. 2001 Feb;
353(Pt 3):673-80.
PMID: 11171065
The ontogeny of the following peroxisomal metabolic pathways was evaluated in mouse liver and brain: alpha-oxidation, beta-oxidation and ether phospholipid synthesis. In mouse embryos lacking functional peroxisomes (PEX5(-/-) knock-out), a...
6.
Baes M, Huyghe S, Carmeliet P, Declercq P, Collen D, Mannaerts G, et al.
J Biol Chem
. 2000 Apr;
275(21):16329-36.
PMID: 10748062
According to current views, peroxisomal beta-oxidation is organized as two parallel pathways: the classical pathway that is responsible for the degradation of straight chain fatty acids and a more recently...
7.
Bladergroen B, Geelen M, Reddy A, Declercq P, Van Golde L
Biochem J
. 1998 Sep;
334 ( Pt 3):511-7.
PMID: 9729455
Previous studies with electropermeabilized cells have suggested the occurrence of metabolic compartmentation and Ca2+-dependent channeling of intermediates of phosphatidylcholine (PC) biosynthesis in C6 rat glioma cells. With a more accessible...
8.
9.
De Groote K, Naesens L, Balzarini J, Baes M, Declercq P
Biochem Pharmacol
. 1997 Oct;
54(6):713-9.
PMID: 9310348
Both 2',3'-dideoxycytidine (ddC) and 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) inhibit the synthesis of the major phospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE) in permeabilized rat hepatocytes. For PC, this appears to be based...
10.
Baes M, Gressens P, BAUMGART E, Carmeliet P, Casteels M, Fransen M, et al.
Nat Genet
. 1997 Sep;
17(1):49-57.
PMID: 9288097
The cerebro-hepato-renal syndrome of Zellweger is a fatal inherited disease caused by deficient import of peroxisomal matrix proteins. The pathogenic mechanisms leading to extreme hypotonia, severe mental retardation and early...