G P Mannaerts
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Explore the profile of G P Mannaerts including associated specialties, affiliations and a list of published articles.
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143
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2353
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Recent Articles
1.
Casteels M, Sniekers M, Fraccascia P, Mannaerts G, Van Veldhoven P
Biochem Soc Trans
. 2007 Oct;
35(Pt 5):876-80.
PMID: 17956236
2-Hydroxyphytanoyl-CoA lyase (abbreviated as 2-HPCL), renamed to 2-hydroxyacyl-CoA lyase (abbreviated as HACL1), is the first peroxisomal enzyme in mammals that has been found to be dependent on TPP (thiamin pyrophosphate)....
2.
Vastiau I, Anthonio E, Brams M, Brees C, Young S, Van de Velde S, et al.
Cell Mol Life Sci
. 2006 Jun;
63(14):1686-99.
PMID: 16791427
Pex19p exhibits a broad binding specificity for peroxisomal membrane proteins (PMPs), and is essential for the formation of functional peroxisomal membranes. Pex19p orthologues contain a C-terminal CAAX motif common to...
3.
Sniekers M, Foulon V, Mannaerts G, Van Maldergem L, Mandel H, Gelb B, et al.
Cell Mol Life Sci
. 2006 Jun;
63(13):1553-63.
PMID: 16786225
The identification of 2-hydroxyphytanoyl-CoA lyase (2-HPCL), a thiamine pyrophosphate (TPP)-dependent peroxisomal enzyme involved in the alpha-oxidation of phytanic acid and of 2-hydroxy straight chain fatty acids, pointed towards a role...
4.
Baes M, Gressens P, Huyghe S, De N, Qi C, Jia Y, et al.
J Neuropathol Exp Neurol
. 2002 Apr;
61(4):368-74.
PMID: 11939592
The purpose of this study was to investigate whether deficient peroxisomal beta-oxidation is causally involved in the neuronal migration defect observed in Pex5 knockout mice. These mice are models for...
5.
Amery L, Mannaerts G, Subramani S, Van Veldhoven P, Fransen M
Comb Chem High Throughput Screen
. 2001 Oct;
4(7):545-52.
PMID: 11669066
Recently, we reported the successful use of the gVI-cDNA phage display technology to clone cDNAs coding for novel peroxisomal enzymes by affinity selection using immobilized antisera directed against peroxisomal subfractions...
6.
De Nys K, Meyhi E, Mannaerts G, Fransen M, Van Veldhoven P
Biochim Biophys Acta
. 2001 Aug;
1533(1):66-72.
PMID: 11514237
Based on the primary structure of the rat peroxisomal 2,4-dienoyl-CoA reductase (M. Fransen, P.P. Van Veldhoven, S. Subramani, Biochem. J. 340 (1999) 561-568), the cDNA of the human counterpart was...
7.
Van Veldhoven P, Meyhi E, Squires R, Fransen M, Fournier B, Brys V, et al.
Eur J Clin Invest
. 2001 Jul;
31(8):714-22.
PMID: 11473573
Background: 2-Methylacyl-CoA racemase interconverts the 2-methyl group of pristanoyl-CoA or the 25-methyl group of hydroxylated cholestanoyl-CoAs, allowing further peroxisomal desaturation of these compounds in man by the branched chain acyl-CoA...
8.
Amery L, Sano H, Mannaerts G, Snider J, Van Looy J, Fransen M, et al.
Biochem J
. 2001 Jul;
357(Pt 3):635-46.
PMID: 11463335
Based on peroxin protein 5 (Pex5p) homology searches in the expressed sequence tag database and sequencing of large full-length cDNA inserts, three novel and related human cDNAs were identified. The...
9.
Fransen M, Wylin T, Brees C, Mannaerts G, Van Veldhoven P
Mol Cell Biol
. 2001 Jun;
21(13):4413-24.
PMID: 11390669
The molecular machinery underlying peroxisomal membrane biogenesis is not well understood. The observation that cells deficient in the peroxins Pex3p, Pex16p, and Pex19p lack peroxisomal membrane structures suggests that these...
10.
van Houte H, de Hoffmann E, Van Veldhoven P, Mannaerts G, Carchon H, Baes M, et al.
Lipids
. 2001 Jun;
36(4):367-72.
PMID: 11383687
The goal of this study was to clarify the mechanism responsible for the catabolism of alpha-tocopherol. The vitamin, bound to albumin, was incubated with rat liver microsomes and appeared to...