P D Roepe
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Explore the profile of P D Roepe including associated specialties, affiliations and a list of published articles.
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43
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1190
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Recent Articles
1.
Siriwardana A, Iyengar K, Roepe P
Antimicrob Agents Chemother
. 2016 Sep;
60(11):6952-6956.
PMID: 27600038
The ring-stage susceptibility assay was modified to quantify the susceptibilities of multiple strains of control and delayed-clearance phenotype (DCP) Plasmodium falciparum strains to seven endoperoxide antimalarial drugs. The susceptibility of...
2.
HOWARD E, Zhang H, Roepe P
J Membr Biol
. 2002 Nov;
190(1):1-8.
PMID: 12422267
The elucidation of the molecular details of drug resistance phenomena is a very active area of research that crosses many disciplinary boundaries. Drug resistance is due to altered drug-target interaction,...
3.
Roepe P
Novartis Found Symp
. 2001 Dec;
240:232-47; discussion 247-50, 265-8.
PMID: 11727933
Most chemotherapeutic drugs in use today are hydrophobic small molecules that are also typically either weakly basic, weakly acidic or charged. Thus, changes in the electrochemical parameters of tumour cell...
4.
Mehlotra R, Fujioka H, Roepe P, Janneh O, Ursos L, McNamara D, et al.
Proc Natl Acad Sci U S A
. 2001 Oct;
98(22):12689-94.
PMID: 11675500
The mechanistic basis for chloroquine resistance (CQR) in Plasmodium falciparum recently has been linked to the polymorphic gene pfcrt. Alleles associated with CQR in natural parasite isolates harbor threonine (T),...
5.
Ursos L, DuBay K, Roepe P
Mol Biochem Parasitol
. 2001 Feb;
112(1):11-7.
PMID: 11166382
Recently, we measured a more acid digestive vacuolar pH for drug resistant Plasmodium falciparum [Dzekunov S, Ursos LMB, Roepe PD. Mol Biochem Parasitol 2000;in press; Ursos LMB, Dzekunov S, Roepe...
6.
7.
Fidock D, Nomura T, Talley A, Cooper R, Dzekunov S, Ferdig M, et al.
Mol Cell
. 2000 Nov;
6(4):861-71.
PMID: 11090624
The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors a 13-exon gene, pfcrt, having...
8.
Ursos L, Dzekunov S, Roepe P
Mol Biochem Parasitol
. 2000 Sep;
110(1):125-34.
PMID: 10989150
In the preceding paper, we present a novel method for measuring the digestive vacuolar pH (pH(vac)) of the malarial parasite Plasmodium falciparum, and show that, surprisingly, pH(vac) is lower for...
9.
Dzekunov S, Ursos L, Roepe P
Mol Biochem Parasitol
. 2000 Sep;
110(1):107-24.
PMID: 10989149
We present the first single cell-level analysis of digestive vacuolar pH for representative chloroquine resistant (strain Dd2) versus sensitive (strain HB3) malarial parasites. Human red blood cells harboring intact intraerythrocytic...
10.
Roepe P
Curr Pharm Des
. 2000 Jan;
6(3):241-60.
PMID: 10637378
Elucidating the molecular function of hu MDR 1 protein (also called P-glycoprotein or P-gp 1) and the precise role this protein plays in clinically relevant tumor drug resistance remains a...