P Costelli
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Explore the profile of P Costelli including associated specialties, affiliations and a list of published articles.
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57
Citations
1511
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Recent Articles
1.
Penna F, Pin F, Ballaro R, Baccino F, Costelli P
Expert Opin Investig Drugs
. 2015 Nov;
25(1):63-72.
PMID: 26560328
Introduction: Cachexia is a syndrome characterized by body weight loss, muscle wasting and metabolic abnormalities, that frequently complicates the management of people affected by chronic diseases. No effective therapy is...
2.
Minero V, De Stefanis D, Costelli P, Baccino F, Bonelli G
Cell Cycle
. 2015 Jan;
14(7):1090-102.
PMID: 25564714
High mortality among hepatocellular carcinoma (HCC) patients reflects both late diagnosis and low curability, due to pharmacoresistance. Taxol (TAX) is toxic for many human HCC-derived cell lines, yet its clinical...
3.
Gallo S, Gatti S, Sala V, Albano R, Costelli P, Casanova E, et al.
Cell Death Dis
. 2014 Apr;
5:e1185.
PMID: 24743740
Met, the tyrosine kinase receptor for hepatocyte growth factor (HGF), mainly activates prosurvival pathways, including protection from apoptosis. In this work, we investigated the cardioprotective mechanisms of Met activation by...
4.
Argiles J, Costelli P, Carbo N, Lopezsoriano F
Oncol Rep
. 2011 May;
3(4):687-90.
PMID: 21594436
The present study focuses on the role of branched-chain amino acids (BCAA) (leucine, isoleucine and valine) in cancer cachexia. This is a frequent and devastating complication of cancer occurring in...
5.
Muscaritoli M, Anker S, Argiles J, Aversa Z, Bauer J, Biolo G, et al.
Clin Nutr
. 2010 Jan;
29(2):154-9.
PMID: 20060626
Chronic diseases as well as aging are frequently associated with deterioration of nutritional status, loss muscle mass and function (i.e. sarcopenia), impaired quality of life and increased risk for morbidity...
6.
Penna F, Bonelli G, Baccino F, Costelli P
Curr Med Chem
. 2009 Dec;
17(4):309-20.
PMID: 20015045
The biological activity of peroxisome proliferators (PPs) is mediated by a class of receptors, known as PPARs (PP-Activated Receptor), belonging to the nuclear receptor superfamily. Upon ligand binding, PPARs dimerize...
7.
Bonetto A, Penna F, Minero V, Reffo P, Bonelli G, Baccino F, et al.
Curr Cancer Drug Targets
. 2009 Jun;
9(5):608-16.
PMID: 19508174
Muscle wasting, as occurring in cancer cachexia, is primarily characterized by protein hypercatabolism and increased expression of ubiquitin ligases, such as atrogin-1/MAFbx and MuRF-1. Myostatin, a member of the TGFbeta...
8.
Penna F, Reffo P, Muzio G, Canuto R, Baccino F, Bonelli G, et al.
Biochem Pharmacol
. 2008 Nov;
77(2):169-76.
PMID: 18983831
Peroxisome proliferators (PPs) are a class of compounds that exert their nominal effects through the peroxisome proliferator-activated receptors. PPs, among which clofibrate (CF), have been extensively studied for their hepatocarcinogenic...
9.
Costelli P, Muscaritoli M, Bonetto A, Penna F, Reffo P, Bossola M, et al.
Eur J Clin Invest
. 2008 Jun;
38(7):531-8.
PMID: 18578694
Background/aims: Myostatin belongs to the transforming growth factor-beta superfamily and negatively regulates skeletal muscle mass. Its deletion induces muscle overgrowth, while, on the contrary, its overexpression or systemic administration cause...
10.
Costelli P, Muscaritoli M, Bossola M, Moore-Carrasco R, Crepaldi S, Grieco G, et al.
Int J Oncol
. 2005 May;
26(6):1663-8.
PMID: 15870883
Cachexia is a syndrome characterized by profound skeletal muscle wasting that frequently complicates malignancies. A number of studies indicate that protein hypercatabolism, largely mediated by classical hormones and cytokines, is...