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P C Zamecnik

Explore the profile of P C Zamecnik including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 142
Citations 2896
Followers 0
Related Specialties
Science
Biochemistry
Biophysics
Top 10 Co-Authors
M L Stephenson
E Rapaport
J C AUB
S Agrawal
P S SARIN
I T NATHANSON
J F Scott
J C Long
J Goodchild
L I Hecht
Published In
Proc Natl Acad Sci U S A
Biochim Biophys Acta
J Biol Chem
J Clin Invest
Biochem Biophys Res Commun
Affiliations
Soon will be listed here.
Recent Articles
1.
History of antisense oligonucleotides
Zamecnik P
Methods Mol Med . 2011 Mar; 1:1-11. PMID: 21359714
Biological science is a rapidly flowing experimental stream, at times encountering a dam that impedes further progress. At such a pomt, a single crack may induce a major breakthrough Discovery...
2.
The toxic factors in experimental traumatic shock; the toxic influence of the bacterial flora, particularly Clostridium welchii, in exudates of ischemic muscle
Pope A, Zamecnik P
J Clin Invest . 2010 Oct; 24:856-63. PMID: 21010040
No abstract available.
3.
The toxic factors in experimental traumatic shock; chemical and enzymatic properties of muscle exudate
Zamecnik P, AUB J
J Clin Invest . 2010 Oct; 24:850-5. PMID: 21010039
No abstract available.
4.
Protection of animals against Cl. welchii (type A) toxin by injection of certain purified lipids
Zamecnik P, Folch J, Brewster L
Proc Soc Exp Biol Med . 2010 Oct; 60:33-9. PMID: 21004025
No abstract available.
5.
Medical Survey of Nutrition in Newfoundland
Adamson J, JOLLIFFE N, KRUSE H, LOWRY O, Moore P, Platt B, et al.
Can Med Assoc J . 2010 Mar; 52(3):227-50. PMID: 20323369
No abstract available.
6.
A manometric method for determining the kinetics of an enzymatic hydrolysis of peptides
Zamecnik P, Stephenson M
J Biol Chem . 2010 Mar; 169(2):349-57. PMID: 20251454
No abstract available.
7.
A STUDY OF THE COMPETITION OF LECITHIN AND ANTITOXIN FOR CL. WELCHII LECITHINASE
Zamecnik P, LIPMANN F
J Exp Med . 2009 Oct; 85(4):395-403. PMID: 19871624
Lecithin has been found to interfere with the combining reaction of Cl. welchii alpha toxin (lecithinase) and its antitoxin. If the lecithinase is first brought into contact with lecithin, and...
8.
A MANOMETRIC METHOD FOR MEASURING THE ACTIVITY OF THE CL. WELCHII LECITHINASE AND A DESCRIPTION OF CERTAIN PROPERTIES OF THIS ENZYME
Zamecnik P, Brewster L, LIPMANN F
J Exp Med . 2009 Oct; 85(4):381-94. PMID: 19871623
A manometric method has been described for measurement of the activity of Cl. welchii lecithinase. The method depends on displacement of carbon dioxide from a bicarbonate-carbon dioxide-buffered medium by the...
9.
Detection of inflamed atherosclerotic lesions with diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A) and positron-emission tomography
Elmaleh D, Fischman A, Tawakol A, Zhu A, Shoup T, Hoffmann U, et al.
Proc Natl Acad Sci U S A . 2006 Oct; 103(43):15992-6. PMID: 17038498
Diadenosine-5',5'''-P(1),P(4)-tetraphosphate (Ap(4)A) and its analog P(2),P(3)-monochloromethylene diadenosine-5',5'''-P(1),P(4)-tetraphosphate (AppCHClppA) are competitive inhibitors of adenosine diphosphate-induced platelet aggregation, which plays a central role in arterial thrombosis and plaque formation. In this study,...
10.
Treatment of Mycobacterium tuberculosis with antisense oligonucleotides to glutamine synthetase mRNA inhibits glutamine synthetase activity, formation of the poly-L-glutamate/glutamine cell wall structure, and bacterial replication
Harth G, Zamecnik P, Tang J, Tabatadze D, Horwitz M
Proc Natl Acad Sci U S A . 2000 Jan; 97(1):418-23. PMID: 10618433
New antibiotics to combat the emerging pandemic of drug-resistant strains of Mycobacterium tuberculosis are urgently needed. We have investigated the effects on M. tuberculosis of phosphorothioate-modified antisense oligodeoxyribonucleotides (PS-ODNs) against...