P Brent Ferrell
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Explore the profile of P Brent Ferrell including associated specialties, affiliations and a list of published articles.
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20
Citations
334
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Recent Articles
1.
Kohutek Z, Caslin H, Fehrenbach D, Heimlich J, Brown J, Madhur M, et al.
Circ Res
. 2025 Jan;
136(3):325-353.
PMID: 39883790
Cardiovascular and cardiometabolic diseases are leading causes of morbidity and mortality worldwide, driven in part by chronic inflammation. Emerging research suggests that the bone marrow microenvironment, or marrow niche, plays...
2.
Jenkins M, Chu Y, Franceski A, Potts C, Dubin R, Dickerson K, et al.
Exp Hematol
. 2025 Jan;
144:104727.
PMID: 39855457
Signaling responses to cytokines are disrupted in clonal hematopoiesis and myeloid malignancies. To better identify specific signaling response alterations in the presence or absence of TET2, we developed a 36-parameter...
3.
Cortes J, Roboz G, Baer M, Jonas B, Schiller G, Yee K, et al.
J Hematol Oncol
. 2025 Jan;
18(1):7.
PMID: 39819505
Background: Olutasidenib is a potent, selective, oral, small molecule inhibitor of mutant IDH1 (mIDH1) which induced durable remissions in high-risk, relapsed/refractory (R/R) mIDH1 AML patients in a phase 1/2 trial....
4.
Parker A, Van Amburg J, Van Amburg J, Heimlich J, Pershad Y, Mickels N, et al.
Blood
. 2024 Nov;
145(9):988-992.
PMID: 39565983
We have developed a cost-effective DNA methylation sequencing assay to improve monitoring of clonal hematopoiesis. By inferring cell-type proportions, this method enhances interpretation of clonal trajectories compared with interpretation based...
5.
Tentori C, Zhao L, Tinterri B, Strange K, Zoldan K, Dimopoulos K, et al.
Hemasphere
. 2024 May;
8(5):e64.
PMID: 38756352
Advancements in comprehending myelodysplastic neoplasms (MDS) have unfolded significantly in recent years, elucidating a myriad of cellular and molecular underpinnings integral to disease progression. While molecular inclusions into prognostic models...
6.
Shannon M, Heimlich J, Olson S, Debevec A, Copeland Z, Kishtagari A, et al.
Blood Adv
. 2024 Apr;
8(13):3453-3463.
PMID: 38608257
Clonal hematopoiesis (CH) is an age-associated phenomenon leading to an increased risk of both hematologic malignancy and nonmalignant organ dysfunction. Increasingly available genetic testing has made the incidental discovery of...
7.
Cortes J, Jonas B, Schiller G, Mims A, Roboz G, Wei A, et al.
Leuk Lymphoma
. 2024 Mar;
65(8):1145-1152.
PMID: 38538632
Olutasidenib, a potent, selective, oral, mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor, is FDA-approved for relapsed/refractory (R/R) acute myeloid leukemia (AML). Here we report efficacy and safety of olutasidenib in 18...
8.
Heimlich J, Bhat P, Parker A, Jenkins M, Vlasschaert C, Ulloa J, et al.
Blood Adv
. 2024 Mar;
8(14):3665-3678.
PMID: 38507736
Clonal hematopoiesis (CH) is an age-associated phenomenon that increases the risk of hematologic malignancy and cardiovascular disease. CH is thought to enhance disease risk through inflammation in the peripheral blood.1...
9.
Moyo T, Kishtagari A, Villaume M, McMahon B, Mohan S, Stopczynski T, et al.
Clin Cancer Res
. 2023 Apr;
29(13):2375-2384.
PMID: 37036505
Purpose: Treatment options are limited beyond JAK inhibitors for patients with primary myelofibrosis (MF) or secondary MF. Preclinical studies have revealed that PI3Kδ inhibition cooperates with ruxolitinib, a JAK1/2 inhibitor,...
10.
Greenwood D, Ramsey H, Nguyen P, Patterson A, Voss K, Bader J, et al.
Immunohorizons
. 2022 Dec;
6(12):837-850.
PMID: 36547387
Hematopoiesis integrates cytokine signaling, metabolism, and epigenetic modifications to regulate blood cell generation. These processes are linked, as metabolites provide essential substrates for epigenetic marks. In this study, we demonstrate...