Jonathan M Irish
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Explore the profile of Jonathan M Irish including associated specialties, affiliations and a list of published articles.
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3424
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Recent Articles
1.
Froese J, Balsamo J, Reisman B, Barone S, Irish J, Bachmann B
J Antibiot (Tokyo)
. 2024 Dec;
78(2):78-89.
PMID: 39643649
Chemical and biological stimulus screening in a hypogean actinomycete was used to elicit secondary metabolism. Optimal biosynthesis of bioactive natural products was identified using Multiplexed Activity Profiling for determining dose-dependent...
2.
Syrimi E, Khan N, Murray P, Willcox C, Haigh T, Willcox B, et al.
iScience
. 2024 Sep;
27(9):110837.
PMID: 39310750
Systemic immunity plays an important role in cancer immune surveillance and response to therapy, but little is known about the immune status of children with solid cancers. We performed a...
3.
Voss K, Bartkowiak T, Sewell A, Chi C, Landis M, Schaefer S, et al.
Immunohorizons
. 2024 Jul;
8(7):492-499.
PMID: 39008056
The transcription factor FOXN1 plays an established role in thymic epithelial development to mediate selection of maturing thymocytes. Patients with heterozygous loss-of-function FOXN1 variants are associated with T cell lymphopenia...
4.
Thirman H, Hayes M, Brown L, Porco Jr J, Irish J
bioRxiv
. 2024 Jun;
PMID: 38826485
A central challenge in chemical biology is to distinguish molecular families in which small structural changes trigger large changes in cell biology. Such families might be ideal scaffolds for developing...
5.
Tentori C, Zhao L, Tinterri B, Strange K, Zoldan K, Dimopoulos K, et al.
Hemasphere
. 2024 May;
8(5):e64.
PMID: 38756352
Advancements in comprehending myelodysplastic neoplasms (MDS) have unfolded significantly in recent years, elucidating a myriad of cellular and molecular underpinnings integral to disease progression. While molecular inclusions into prognostic models...
6.
Cross C, Mayeda C, Medina S, Hayes M, Kaviany S, Connelly J, et al.
bioRxiv
. 2024 May;
PMID: 38746337
A key challenge for single cell discovery analysis is to identify new cell types, describe them quantitatively, and seek these novel cells in new studies often using a different platform....
7.
Canderan G, Muehling L, Kadl A, Ladd S, Bonham C, Cross C, et al.
bioRxiv
. 2024 Apr;
PMID: 38617217
The variable etiology of persistent breathlessness after COVID-19 have confounded efforts to decipher the immunopathology of lung sequelae. Here, we analyzed hundreds of cellular and molecular features in the context...
8.
Medina S, Brockman A, Cross C, Hayes M, Mobley B, Mistry A, et al.
bioRxiv
. 2024 Apr;
PMID: 38585888
Adult IDH-wildtype glioblastoma (GBM) is a highly aggressive brain tumor with no established immunotherapy or targeted therapy. Recently, CD32 HLA-DR macrophages were shown to have displaced resident microglia in GBM...
9.
von Lersner A, Fernandes F, Ozawa P, Jackson M, Masureel M, Ho H, et al.
ACS Nano
. 2024 Apr;
18(15):10464-10484.
PMID: 38578701
Mammalian cells release a heterogeneous array of extracellular vesicles (EVs) that contribute to intercellular communication by means of the cargo that they carry. To resolve EV heterogeneity and determine if...
10.
Bewersdorf J, Shallis R, Sharon E, Park S, Ramaswamy R, Roe C, et al.
Ann Hematol
. 2023 Nov;
103(1):105-116.
PMID: 38036712
Patients with myelodysplastic syndromes/neoplasms (MDS) or acute myeloid leukemia (AML) with hypomethylating agent failure have a poor prognosis. Myeloid-derived suppressor cells (MDSCs) can contribute to MDS progression and mediate resistance...