Osami Kanagawa
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Explore the profile of Osami Kanagawa including associated specialties, affiliations and a list of published articles.
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3200
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Recent Articles
11.
Nakagawa Y, Ohigashi I, Nitta T, Sakata M, Tanaka K, Murata S, et al.
Proc Natl Acad Sci U S A
. 2012 Nov;
109(50):20572-7.
PMID: 23188800
Distinct subsets of thymic epithelial cells (TECs) support T-cell development and selection. Isolated TECs contain multicellular complexes that enclose many viable thymocytes. However, the functions of those TECs, termed thymic...
12.
Takase M, Iida R, Maruya M, Sakaue-Sawano A, Miyawaki A, Wakayama T, et al.
Int Immunol
. 2012 Oct;
25(3):145-56.
PMID: 23042789
The transfer of nuclei of fully differentiated cells into enucleated oocytes is a well-recognized method for the generation of embryonic stem (ES) cells. Here, we demonstrate that nuclear transferred ES...
13.
Asano K, Nabeyama A, Miyake Y, Qiu C, Kurita A, Tomura M, et al.
Immunity
. 2011 Jan;
34(1):85-95.
PMID: 21194983
The generation of tumor-directed cytotoxic T lymphocytes is considered crucial for the induction of antitumor immunity. To activate these CD8(+) T cells, antigen-presenting cells (APCs) must initially acquire tumor cell-associated...
14.
Maruya M, Suzuki K, Fujimoto H, Miyajima M, Kanagawa O, Wakayama T, et al.
Proc Natl Acad Sci U S A
. 2010 Dec;
108(2):722-7.
PMID: 21187378
B1 cells represent a distinct subset of B cells that produce most of the natural serum IgM and much of the gut IgA and function as an important component of...
15.
Ota N, Takase M, Uchiyama H, Olsen S, Kanagawa O
J Immunol
. 2010 Oct;
185(10):6041-8.
PMID: 20926799
The trans presentation of IL-15 by cells expressing the specific high-affinity receptor α-chain (IL-15Rα) to cells expressing the signaling receptor β-chain and γ-chain is essential for the generation and maintenance...
16.
Aiba Y, Kometani K, Hamadate M, Moriyama S, Sakaue-Sawano A, Tomura M, et al.
Proc Natl Acad Sci U S A
. 2010 Jun;
107(27):12192-7.
PMID: 20547847
It has long been presumed that after leaving the germinal centers (GCs), memory B cells colonize the marginal zone or join the recirculating pool. Here we demonstrate the preferential localization...
17.
Tomura M, Itoh K, Kanagawa O
J Immunol
. 2010 Mar;
184(9):4646-53.
PMID: 20304829
Naive T lymphocytes recirculate through the lymph-vascular system and enter and exit lymphoid organs. Using mice expressing the photoconvertible fluorescence protein Kaede, we demonstrated that naive T cells seek to...
18.
Fagarasan S, Kawamoto S, Kanagawa O, Suzuki K
Annu Rev Immunol
. 2010 Mar;
28:243-73.
PMID: 20192805
In mammals, the gastrointestinal tract harbors an extraordinarily dense and complex community of microorganisms. The gut microbiota provide strong selective pressure to the host to evolve adaptive immune responses required...
19.
Epidermal gammadelta T cells sense precancerous cellular dysregulation and initiate immune responses
Shimura E, Hozumi N, Kanagawa O, Metzger D, Chambon P, Radtke F, et al.
Int Immunol
. 2010 Feb;
22(4):329-40.
PMID: 20185432
Hyperplasia associated with a loss of tissue homeostasis can induce DNA replication stress, leading to precancerous dysregulation. Epidermal gammadelta T cells reside in the primary barrier that protects against diverse...
20.
Tomura M, Honda T, Tanizaki H, Otsuka A, Egawa G, Tokura Y, et al.
J Clin Invest
. 2010 Feb;
120(3):883-93.
PMID: 20179354
Tregs play an important role in protecting the skin from autoimmune attack. However, the extent of Treg trafficking between the skin and draining lymph nodes (DLNs) is unknown. We set...