Sidonia Fagarasan
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Explore the profile of Sidonia Fagarasan including associated specialties, affiliations and a list of published articles.
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62
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6620
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Recent Articles
1.
Zhang B, Fagarasan S
Curr Opin Immunol
. 2025 Jan;
93:102525.
PMID: 39827832
Energy metabolism of immune cells, such as glycolysis and mitochondrial activity, requires strict regulation. This is especially critical in the complex environment of the bone marrow (BM), where there is...
2.
Sutherland D, Kato L, Fagarasan S
Trends Immunol
. 2024 Nov;
45(12):928-930.
PMID: 39603890
The recent discovery by Lu and colleagues of Tomasiella immunophila, a bacterium that degrades IgA, offers insights into microbial influences on mucosal immunity and evolutionary immune trade-offs. By modulating IgA...
3.
Chamoto K, Zhang B, Tajima M, Honjo T, Fagarasan S
Trends Cell Biol
. 2023 Sep;
34(5):363-370.
PMID: 37723019
Polyamines - putrescine, spermidine, and spermine - are widely distributed aliphatic compounds known to regulate important biological processes in prokaryotic and eukaryotic cells. Therefore, spermidine insufficiency is associated with various...
4.
Zhang B, Vogelzang A, Fagarasan S
Trends Immunol
. 2022 Nov;
43(12):990-1005.
PMID: 36347788
Metabolites are emerging as essential factors for the immune system that are involved in both metabolic circuits and signaling cascades. Accumulated evidence suggests that altered metabolic programs initiated by the...
5.
Al-Habsi M, Chamoto K, Matsumoto K, Nomura N, Zhang B, Sugiura Y, et al.
Science
. 2022 Oct;
378(6618):eabj3510.
PMID: 36302005
Spermidine (SPD) delays age-related pathologies in various organisms. SPD supplementation overcame the impaired immunotherapy against tumors in aged mice by increasing mitochondrial function and activating CD8 T cells. Treatment of...
6.
Zhang B, Vogelzang A, Miyajima M, Sugiura Y, Wu Y, Chamoto K, et al.
Nature
. 2021 Nov;
599(7885):471-476.
PMID: 34732892
Small, soluble metabolites not only are essential intermediates in intracellular biochemical processes, but can also influence neighbouring cells when released into the extracellular milieu. Here we identify the metabolite and...
7.
Shirakashi M, Maruya M, Hirota K, Tsuruyama T, Matsuo T, Watanabe R, et al.
Arthritis Rheumatol
. 2021 Nov;
74(4):641-653.
PMID: 34725966
Objective: T cell receptor (TCR) signaling abnormalities and gut dysbiosis are thought to be involved in the development of systemic lupus erythematosus (SLE). However, it is not known whether these...
8.
Akrami M, Menzies R, Chamoto K, Miyajima M, Suzuki R, Sato H, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(38):23674-23683.
PMID: 32907933
The gut microbiome has garnered attention as an effective target to boost immunity and improve cancer immunotherapy. We found that B cell-defective (BCD) mice, such as µ-membrane targeted deletion (µMT)...
9.
Guzman-Bautista E, Suzuki K, Asami S, Fagarasan S
Curr Opin Immunol
. 2020 Jul;
66:82-89.
PMID: 32673977
The dialog between microbes and immune cells is critical for the establishment and maintenance of immune homeostasis. Bacterial-derived metabolites or structural components initiate immune signaling pathways and transcriptional factors, inducing...
10.
Hatae R, Chamoto K, Kim Y, Sonomura K, Taneishi K, Kawaguchi S, et al.
JCI Insight
. 2019 Dec;
5(2).
PMID: 31855576
BACKGROUNDCurrent clinical biomarkers for the programmed cell death 1 (PD-1) blockade therapy are insufficient because they rely only on the tumor properties, such as programmed cell death ligand 1 expression...