Juan Jose Bonfiglio
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Explore the profile of Juan Jose Bonfiglio including associated specialties, affiliations and a list of published articles.
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14
Citations
785
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Recent Articles
1.
Longarini E, Dauben H, Locatelli C, Wondisford A, Smith R, Muench C, et al.
Mol Cell
. 2023 Apr;
83(10):1743-1760.e11.
PMID: 37116497
PARP1, an established anti-cancer target that regulates many cellular pathways, including DNA repair signaling, has been intensely studied for decades as a poly(ADP-ribosyl)transferase. Although recent studies have revealed the prevalence...
2.
Pouikli A, Maleszewska M, Parekh S, Yang M, Nikopoulou C, Bonfiglio J, et al.
EMBO J
. 2022 Oct;
41(23):e111239.
PMID: 36278281
Bone-derived mesenchymal stem cells (MSCs) reside in a hypoxic niche that maintains their differentiation potential. While hypoxia (low oxygen concentration) was reported to critically support stem cell function and osteogenesis,...
3.
Bonfiglio J, Leidecker O, Dauben H, Longarini E, Colby T, San Segundo-Acosta P, et al.
Cell
. 2020 Nov;
183(4):1086-1102.e23.
PMID: 33186521
Strategies for installing authentic ADP-ribosylation (ADPr) at desired positions are fundamental for creating the tools needed to explore this elusive post-translational modification (PTM) in essential cellular processes. Here, we describe...
4.
Bartlett E, Bonfiglio J, Prokhorova E, Colby T, Zobel F, Ahel I, et al.
Cell Rep
. 2018 Sep;
24(13):3488-3502.e5.
PMID: 30257210
Serine ADP-ribosylation (Ser-ADPr) is a recently discovered protein modification that is catalyzed by PARP1 and PARP2 when in complex with the eponymous histone PARylation factor 1 (HPF1). In addition to...
5.
Nonlocalized Searching of HCD Data for Fast and Sensitive Identification of ADP-Ribosylated Peptides
Colby T, Bonfiglio J, Matic I
Methods Mol Biol
. 2018 Aug;
1813:255-269.
PMID: 30097874
ADP-ribosylation is a technically challenging PTM which has just emerged into the field of PTM-specific proteomics. But this fragile modifier requires special treatment on both a data acquisition and data...
6.
Crawford K, Bonfiglio J, Mikoc A, Matic I, Ahel I
Crit Rev Biochem Mol Biol
. 2017 Nov;
53(1):64-82.
PMID: 29098880
Proper and timely regulation of cellular processes is fundamental to the overall health and viability of organisms across all kingdoms of life. Thus, organisms have evolved multiple highly dynamic and...
7.
Zhiteneva A, Bonfiglio J, Makarov A, Colby T, Vagnarelli P, Schirmer E, et al.
Open Biol
. 2017 Sep;
7(9).
PMID: 28903997
How eukaryotic chromosomes are compacted during mitosis has been a leading question in cell biology since the nineteenth century. Non-histone proteins such as condensin complexes contribute to chromosome shaping, but...
8.
Fontana P, Bonfiglio J, Palazzo L, Bartlett E, Matic I, Ahel I
Elife
. 2017 Jun;
6.
PMID: 28650317
ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that controls many cellular processes, including DNA repair, transcription, chromatin regulation and mitosis. A number of proteins catalyse the transfer and...
9.
Inda C, Bonfiglio J, Dos Santos Claro P, Senin S, Armando N, Deussing J, et al.
Sci Rep
. 2017 May;
7(1):1944.
PMID: 28512295
Corticotropin-releasing hormone receptor 1 (CRHR1) activates the atypical soluble adenylyl cyclase (sAC) in addition to transmembrane adenylyl cyclases (tmACs). Both cAMP sources were shown to be required for the phosphorylation...
10.
Bonfiglio J, Fontana P, Zhang Q, Colby T, Gibbs-Seymour I, Atanassov I, et al.
Mol Cell
. 2017 Feb;
65(5):932-940.e6.
PMID: 28190768
ADP-ribosylation (ADPr) regulates important patho-physiological processes through its attachment to different amino acids in proteins. Recently, by precision mapping on all possible amino acid residues, we identified histone serine ADPr...