Orit Rozenblatt-Rosen
Overview
Explore the profile of Orit Rozenblatt-Rosen including associated specialties, affiliations and a list of published articles.
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131
Citations
27528
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Recent Articles
11.
Fujita M, Gao Z, Zeng L, McCabe C, White C, Ng B, et al.
Nat Genet
. 2024 Mar;
56(4):605-614.
PMID: 38514782
The relationship between genetic variation and gene expression in brain cell types and subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data from the neocortex of 424 individuals of...
12.
Patel A, Ashenberg O, Collins N, Segerstolpe A, Jiang S, Slyper M, et al.
bioRxiv
. 2024 Jan;
PMID: 38260392
Neuroblastoma is a pediatric cancer arising from the developing sympathoadrenal lineage with complex inter- and intra-tumoral heterogeneity. To chart this complexity, we generated a comprehensive cell atlas of 55 neuroblastoma...
13.
Waghray A, Monga I, Lin B, Shah V, Slyper M, Giotti B, et al.
bioRxiv
. 2023 Dec;
PMID: 38076853
The human airway contains specialized rare epithelial cells whose roles in respiratory disease are not well understood. Ionocytes express the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), while chemosensory tuft cells...
14.
Fiskin E, Eraslan G, Alora-Palli M, Leyva-Castillo J, Kim S, Choe H, et al.
bioRxiv
. 2023 Nov;
PMID: 37961084
In healthy skin, a cutaneous immune system maintains the balance between tolerance towards innocuous environmental antigens and immune responses against pathological agents. In atopic dermatitis (AD), barrier and immune dysfunction...
15.
De Rop F, Hulselmans G, Flerin C, Soler-Vila P, Rafels A, Christiaens V, et al.
Nat Biotechnol
. 2023 Aug;
42(6):916-926.
PMID: 37537502
Single-cell assay for transposase-accessible chromatin by sequencing (scATAC-seq) has emerged as a powerful tool for dissecting regulatory landscapes and cellular heterogeneity. However, an exploration of systemic biases among scATAC-seq technologies...
16.
Zhao W, Kepecs B, Mahadevan N, Segerstolpe A, Weirather J, Besson N, et al.
bioRxiv
. 2023 Jul;
PMID: 37425718
is the most frequently mutated gene across many cancers and is associated with shorter survival in lung adenocarcinoma (LUAD). To define how mutations affect the LUAD tumor microenvironment (TME), we...
17.
Bod L, Kye Y, Shi J, Torlai Triglia E, Schnell A, Fessler J, et al.
Nature
. 2023 Jun;
619(7969):348-356.
PMID: 37344597
The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth. Here, using high-throughput...
18.
Cain A, Taga M, McCabe C, Green G, Hekselman I, White C, et al.
Nat Neurosci
. 2023 Jun;
26(7):1267-1280.
PMID: 37336975
The role of different cell types and their interactions in Alzheimer's disease (AD) is a complex and open question. Here, we pursued this question by assembling a high-resolution cellular map...
19.
Sikkema L, Ramirez-Suastegui C, Strobl D, Gillett T, Zappia L, Madissoon E, et al.
Nat Med
. 2023 Jun;
29(6):1563-1577.
PMID: 37291214
Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many single-cell datasets can...
20.
Comiter C, Vaishnav E, Ciampricotti M, Li B, Yang Y, Rodig S, et al.
bioRxiv
. 2023 Mar;
PMID: 36993643
Tissue biology involves an intricate balance between cell-intrinsic processes and interactions between cells organized in specific spatial patterns, which can be respectively captured by single-cell profiling methods, such as single-cell...