Mario L Suva
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Explore the profile of Mario L Suva including associated specialties, affiliations and a list of published articles.
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85
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12710
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Recent Articles
1.
Miller T, El Farran C, Couturier C, Chen Z, DAntonio J, Verga J, et al.
Nature
. 2025 Feb;
PMID: 40011771
Gliomas are incurable malignancies notable for having an immunosuppressive microenvironment with abundant myeloid cells, the immunomodulatory phenotypes of which remain poorly defined. Here we systematically investigate these phenotypes by integrating...
2.
Mount C, Suva M
Neuron
. 2025 Jan;
113(2):185-186.
PMID: 39848227
Writing in Neuron, Zhang et al. identify a subpopulation of glioblastoma cells from patient tumor samples with progenitor-like features that expresses the potassium ion channel KCND2. In mouse and organoid...
3.
Furth N, Cohen N, Spitzer A, Salame T, Dassa B, Mehlman T, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2403862122.
PMID: 39793065
Malignant gliomas are heterogeneous tumors, mostly incurable, arising in the central nervous system (CNS) driven by genetic, epigenetic, and metabolic aberrations. Mutations in isocitrate dehydrogenase (IDH1/2) enzymes are predominantly found...
4.
Lee J, Tao R, You Z, Haldipur P, Erickson A, Farooq H, et al.
Nat Genet
. 2025 Jan;
57(1):88-102.
PMID: 39753768
Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4)...
5.
Wu J, Gonzalez Castro L, Battaglia S, El Farran C, DAntonio J, Miller T, et al.
Nat Cancer
. 2024 Nov;
6(1):145-157.
PMID: 39572850
Isocitrate dehydrogenase (IDH) mutants define a class of gliomas that are initially slow-growing but inevitably progress to fatal disease. To characterize their malignant cell hierarchy, we profiled chromatin accessibility and...
6.
Mangena V, Chanoch-Myers R, Sartore R, Paulsen B, Gritsch S, Weisman H, et al.
Cancer Discov
. 2024 Oct;
15(2):299-315.
PMID: 39373549
Glioblastoma (GBM) is characterized by heterogeneous malignant cells that are functionally integrated within the neuroglial microenvironment. In this study, we model this ecosystem by growing GBM into long-term cultured human...
7.
Schiffman J, DAvino A, Prieto T, Pang Y, Fan Y, Rajagopalan S, et al.
Nat Genet
. 2024 Sep;
56(10):2174-2184.
PMID: 39317739
Single-cell sequencing has characterized cell state heterogeneity across diverse healthy and malignant tissues. However, the plasticity or heritability of these cell states remains largely unknown. To address this, we introduce...
8.
Tirosh I, Suva M
Cancer Cell
. 2024 Aug;
42(9):1497-1506.
PMID: 39214095
Human tumors are intricate ecosystems composed of diverse genetic clones and malignant cell states that evolve in a complex tumor micro-environment. Single-cell RNA-sequencing (scRNA-seq) provides a compelling strategy to dissect...
9.
Walchli T, Ghobrial M, Schwab M, Takada S, Zhong H, Suntharalingham S, et al.
Nature
. 2024 Jul;
632(8025):603-613.
PMID: 38987604
A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular architecture of the human...
10.
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire C, Ryba A, et al.
Nat Med
. 2024 May;
30(6):1622-1635.
PMID: 38760585
Neural-tumor interactions drive glioma growth as evidenced in preclinical models, but clinical validation is limited. We present an epigenetically defined neural signature of glioblastoma that independently predicts patients' survival. We...