Orazio Prezzavento
Overview
Explore the profile of Orazio Prezzavento including associated specialties, affiliations and a list of published articles.
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65
Citations
610
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Recent Articles
11.
Floresta G, Dichiara M, Gentile D, Prezzavento O, Marrazzo A, Rescifina A, et al.
Int J Mol Sci
. 2019 Jan;
20(3).
PMID: 30678129
Ibogaine is a psychoactive indole alkaloid with high affinity for several targets including the ₂ receptor. Indeed, extensive data support the involvement of the ₂ receptor in neurological disorders, including...
12.
Sorrenti V, Pittala V, Romeo G, Amata E, Dichiara M, Marrazzo A, et al.
Eur J Med Chem
. 2018 Sep;
158:937-950.
PMID: 30261468
Heme oxygenase-1 (HO-1) is a cytoprotective enzyme and a survival-enhancing factor in a number of cancers. Chronic myeloid leukemia (CML) is a blood cancer caused by pathological kinase activity of...
13.
Greish K, Salerno L, Al Zahrani R, Amata E, Modica M, Romeo G, et al.
Molecules
. 2018 May;
23(5).
PMID: 29783634
In this paper, the design, synthesis, and molecular modeling of a new azole-based HO-1 inhibitors was reported, using compound as a lead compound, in which an imidazole moiety is linked...
14.
Floresta G, Amata E, Dichiara M, Marrazzo A, Salerno L, Romeo G, et al.
ChemMedChem
. 2018 Apr;
13(13):1336-1342.
PMID: 29693778
A 3D quantitative structure-activity relationship (3D-QSAR) model for predicting the activity of heme oxygenase 1 (HO-1) inhibitors was constructed with the aim of providing a useful tool for the identification,...
15.
Turnaturi R, Parenti C, Prezzavento O, Marrazzo A, Pallaki P, Georgoussi Z, et al.
Molecules
. 2018 Mar;
23(3).
PMID: 29547588
The opioid pharmacological profile of -(-)--normetazocine derivatives is deeply affected by the nature of their -substituents. Here, our efforts were focused on the synthesis and pharmacological evaluation of novel derivatives...
16.
Salerno L, Amata E, Romeo G, Marrazzo A, Prezzavento O, Floresta G, et al.
Eur J Med Chem
. 2018 Feb;
148:54-62.
PMID: 29454190
Here we report the design, synthesis, and molecular modeling of new potent and selective imidazole-based HO-1 inhibitors in which the imidazole nucleus and the hydrophobic groups are linked by a...
17.
Amata E, Rescifina A, Prezzavento O, Arena E, Dichiara M, Pittala V, et al.
J Med Chem
. 2017 Dec;
61(1):372-384.
PMID: 29220177
Methoxycarbonyl-1-phenyl-2-cyclopropylmethyl based derivatives cis-(+)-1a [cis-(+)-MR200], cis-(-)-1a [cis-(-)-MR201], and trans-(±)-1a [trans-(±)-MR204], have been identified as new potent sigma (σ) receptor ligands. In the present paper, novel enantiomerically pure analogues were synthesized...
18.
Longhitano L, Castruccio Castracani C, Tibullo D, Avola R, Viola M, Russo G, et al.
Oncotarget
. 2017 Dec;
8(53):91099-91111.
PMID: 29207628
Uveal melanoma is the most common primary intraocular tumor in adults, with about 1200-1500 new cases occurring per year in the United States. Metastasis is a frequent occurrence in uveal...
19.
Arena E, Dichiara M, Floresta G, Parenti C, Marrazzo A, Pittala V, et al.
Future Med Chem
. 2017 Nov;
10(2):231-256.
PMID: 29185346
Sigma-1 (σ) receptor has been identified as a chaperone protein that interacts with other proteins, such as N-methyl-D-aspartate (NMDA) and opioid receptors, modulating their activity. σ receptor antagonists have been...
20.
Amata E, Dichiara M, Arena E, Pittala V, Pistara V, Cardile V, et al.
J Med Chem
. 2017 Nov;
60(23):9531-9544.
PMID: 29172528
This contribution reports the synthesis and evaluation of novel hybrid compounds that conjugate a sigma (σ) receptor pharmacophore and a nitric oxide (NO) photodonor. All compounds preserve their capability to...