Olivier B Poirion
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Explore the profile of Olivier B Poirion including associated specialties, affiliations and a list of published articles.
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18
Citations
1314
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Recent Articles
11.
Poirion O, Jing Z, Chaudhary K, Huang S, Garmire L
Genome Med
. 2021 Jul;
13(1):112.
PMID: 34261540
Multi-omics data are good resources for prognosis and survival prediction; however, these are difficult to integrate computationally. We introduce DeepProg, a novel ensemble framework of deep-learning and machine-learning approaches that...
12.
Hocker J, Poirion O, Zhu F, Buchanan J, Zhang K, Chiou J, et al.
Sci Adv
. 2021 May;
7(20).
PMID: 33990324
Misregulated gene expression in human hearts can result in cardiovascular diseases that are leading causes of mortality worldwide. However, the limited information on the genomic location of candidate cis-regulatory elements...
13.
Muus C, Luecken M, Eraslan G, Sikkema L, Waghray A, Heimberg G, et al.
Nat Med
. 2021 Mar;
27(3):546-559.
PMID: 33654293
Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, and their expression may shed light on viral...
14.
Gally F, Sasse S, Kurche J, Gruca M, Cardwell J, Okamoto T, et al.
JCI Insight
. 2020 Dec;
6(2).
PMID: 33320836
The G/T transversion rs35705950, located approximately 3 kb upstream of the MUC5B start site, is the cardinal risk factor for idiopathic pulmonary fibrosis (IPF). Here, we investigate the function and...
15.
Wang A, Chiou J, Poirion O, Buchanan J, Valdez M, Verheyden J, et al.
Elife
. 2020 Nov;
9.
PMID: 33164753
Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-nucleus transcriptomes of 46,500 nuclei in non-diseased...
16.
Chaudhary K, Poirion O, Lu L, Huang S, Ching T, Garmire L
Clin Cancer Res
. 2018 Sep;
25(2):463-472.
PMID: 30242023
Although driver genes in hepatocellular carcinoma (HCC) have been investigated in various previous genetic studies, prevalence of key driver genes among heterogeneous populations is unknown. Moreover, the phenotypic associations of...
17.
Poirion O, Chaudhary K, Garmire L
AMIA Jt Summits Transl Sci Proc
. 2018 Jun;
2017:197-206.
PMID: 29888072
We propose an unsupervised multi-omics integration pipeline, using deep-learning autoencoder algorithm, to predict the survival subtypes in bladder cancer (BC). We used TCGA dataset comprising mRNA, miRNA and methylation to...
18.
Chaudhary K, Poirion O, Lu L, Garmire L
Clin Cancer Res
. 2017 Oct;
24(6):1248-1259.
PMID: 28982688
Identifying robust survival subgroups of hepatocellular carcinoma (HCC) will significantly improve patient care. Currently, endeavor of integrating multi-omics data to explicitly predict HCC survival from multiple patient cohorts is lacking....
19.
Poirion O, Zhu X, Ching T, Garmire L
Front Genet
. 2016 Oct;
7:163.
PMID: 27708664
The emerging single-cell RNA-Seq (scRNA-Seq) technology holds the promise to revolutionize our understanding of diseases and associated biological processes at an unprecedented resolution. It opens the door to reveal intercellular...