O Kan
Overview
Explore the profile of O Kan including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
293
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0
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Recent Articles
1.
Kong J, Kim S, Binley K, Pata I, Doi K, Mannik J, et al.
Gene Ther
. 2008 May;
15(19):1311-20.
PMID: 18463687
Autosomal recessive Stargardt disease (STGD1) is a macular dystrophy caused by mutations in the ABCA4 (ABCR) gene. The disease phenotype that is most recognized in STGD1 patients, and also in...
2.
Balaggan K, Binley K, Esapa M, MacLaren R, Iqball S, Duran Y, et al.
Gene Ther
. 2006 Mar;
13(15):1153-65.
PMID: 16572190
We evaluated the efficacy of equine infectious anaemia virus (EIAV)-based lentiviral vectors encoding endostatin (EIAV.endostatin) or angiostatin (EIAV.angiostatin) in inhibiting angiogenesis and vascular hyperpermeability in the laser-induced model of choroidal...
3.
Balaggan K, Binley K, Esapa M, Iqball S, Askham Z, Kan O, et al.
J Gene Med
. 2005 Nov;
8(3):275-85.
PMID: 16299834
Background: We have developed minimal non-primate lentiviral vectors based on the equine infectious anaemia virus (EIAV). We evaluated the in vivo expression profiles of these vectors delivered regionally to ocular...
4.
Kan O, Griffiths L, Baban D, Iqball S, Uden M, Spearman H, et al.
Cancer Gene Ther
. 2001 Aug;
8(7):473-82.
PMID: 11498768
Human cytochrome P450 2B6 (CYP2B6) metabolizes the prodrug cyclophosphamide (CPA) to produce phosphoramide mustard that cross-links DNA leading to cell death. We have constructed a novel retroviral vector encoding CYP2B6...
5.
Just U, Boettiger D, Kan O, Dexter T, Spooncer E
Curr Top Microbiol Immunol
. 2000 Oct;
251:27-34.
PMID: 11036755
The genes controlling self renewal in the haemopoietic system are still unknown. Using retroviral insertional mutagenesis we have established multipotent haemopoietic stem cell lines (FDCP-mix) that possess an increased self...
6.
Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Ratcliffe P, et al.
Gene Ther
. 2000 Mar;
7(3):255-62.
PMID: 10694803
The use of activated macrophages in the treatment of cancer has been largely ineffectual. By 'arming' these cells with the ability to express a therapeutic gene we demonstrate significant advances...
7.
The Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines
Just U, Kan O, Fennelly J, Dexter T, Spooncer E
Growth Factors
. 1995 Jan;
12(3):173-7.
PMID: 8619923
The establishment of IL-3-dependent multipotent progenitor cell lines from Hox-2.4-expressing bone marrow cells suggests that homeobox genes may contribute to immortalization of early myeloid cells. A survey of 20 independently...
8.
Kan O, Baldwin S, Whetton A
J Exp Med
. 1994 Sep;
180(3):917-23.
PMID: 8064240
In the absence of a survival stimulus, the interleukin 3 (IL-3)-dependent IC.DP cell line undergoes a process termed programmed cell death or apoptosis. Survival can be induced by IL-3, which...
9.
Baldwin S, Kan O, Whetton A, Martin S, Fawcett H, Flint D, et al.
Biochem Soc Trans
. 1994 Aug;
22(3):814-7.
PMID: 7821692
No abstract available.
10.
Kan O, Baldwin S, Whetton A
Biochem Soc Trans
. 1994 Aug;
22(3):275S.
PMID: 7821534
No abstract available.