J W B Bainbridge
Overview
Explore the profile of J W B Bainbridge including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
492
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Recent Articles
1.
Georgiadis A, Duran Y, Ribeiro J, Abelleira-Hervas L, Robbie S, Sunkel-Laing B, et al.
Gene Ther
. 2024 Jul;
31(9-10):524.
PMID: 38997420
No abstract available.
2.
Georgiadis A, Duran Y, Ribeiro J, Abelleira-Hervas L, Robbie S, Sunkel-Laing B, et al.
Gene Ther
. 2018 Jul;
25(6):450.
PMID: 30046128
The authors originally published this article under the incorrect license type; this has now been corrected and is published under the CC-BY license.
3.
Kampik D, Basche M, Luhmann U, Nishiguchi K, Williams J, Greenwood J, et al.
Gene Ther
. 2017 Dec;
24(12):810-818.
PMID: 29188796
The retinal pigment epithelium (RPE) interacts closely with photoreceptors to maintain visual function. In degenerative diseases such as Stargardt disease and age-related macular degeneration, the leading cause of blindness in...
4.
Georgiadis A, Duran Y, Ribeiro J, Abelleira-Hervas L, Robbie S, Sunkel-Laing B, et al.
Gene Ther
. 2016 Sep;
23(12):857-862.
PMID: 27653967
Leber congenital amaurosis is a group of inherited retinal dystrophies that cause severe sight impairment in childhood; RPE65-deficiency causes impaired rod photoreceptor function from birth and progressive impairment of cone...
5.
Mowat F, Breuwer A, Bartoe J, Annear M, Zhang Z, Smith A, et al.
Gene Ther
. 2012 Sep;
20(5):545-55.
PMID: 22951453
Recent clinical trials of retinal pigment epithelium gene (RPE65) supplementation therapy in Leber congenital amaurosis type 2 patients have demonstrated improvements in rod and cone function, but it may be...
6.
Balaggan K, Duran Y, Georgiadis A, Thaung C, Barker S, Buch P, et al.
Gene Ther
. 2011 Nov;
19(2):182-8.
PMID: 22113317
Insertional mutagenesis following gene therapy with gammaretroviral vectors can cause the development of lymphoproliferation in children with X-linked severe combined immunodeficiency. In experimental studies, recombinant adeno-associated virus (rAAV) vectors have...
7.
Smith A, Bainbridge J, Ali R
Gene Ther
. 2011 Oct;
19(2):154-61.
PMID: 22033465
Over the last decade, gene supplementation therapy for inherited retinal degeneration has come of age. Early proof-of-concept studies in animal models of disease showed modest, but genuine improvements in retinal...
8.
Georgiadis A, Tschernutter M, Bainbridge J, Robbie S, McIntosh J, Nathwani A, et al.
Gene Ther
. 2009 Dec;
17(4):486-93.
PMID: 20010626
Gene therapy for inherited retinal degeneration in which expression of a mutant allele has a gain-of-function effect on photoreceptor cells is likely to depend on efficient silencing of the mutated...
9.
Bainbridge J
Eye (Lond)
. 2009 Jan;
23(10):1898-903.
PMID: 19151647
Gene-based therapies offer the means to address gene defects responsible for inherited retinal disorders. A number of studies in experimental and preclinical models have demonstrated proof-of-principle that gene replacement therapy...
10.
Trittibach P, Barker S, Broderick C, Natkunarajah M, Duran Y, Robbie S, et al.
Gene Ther
. 2008 Jun;
15(22):1478-88.
PMID: 18580969
Uveitis is a sight threatening inflammatory disorder that remains a significant cause of visual loss. We investigated lentiviral gene delivery of interleukin 1 receptor antagonist (IL-1ra) or interleukin (IL)-10 to...