Nobumoto Watanabe
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Explore the profile of Nobumoto Watanabe including associated specialties, affiliations and a list of published articles.
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73
Citations
949
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Recent Articles
1.
Watanabe N, Sanada E, Okano A, Nogawa T, Lai N, Mazaki Y, et al.
FEBS Lett
. 2024 Dec;
599(5):755-765.
PMID: 39727141
FOXO3a is a transcription factor involved in cell growth inhibition and apoptosis. FOXO3a is localized in the cytoplasm in cancer cells, and its nuclear translocation by small molecules is expected...
2.
Mao T, Wei W, Chen B, Chen Y, Liang S, Chen G, et al.
Cell Mol Biol Lett
. 2024 Dec;
29(1):147.
PMID: 39623319
Background: Sjögren's syndrome (SS) is an autoimmune disease with limited effective treatment options. This study aimed to explore the underlying mechanism by which genistein-estrogen receptor alpha (ERα) complex targets X-inactive...
3.
Liu F, Wu Q, Liu Q, Chen B, Liu X, Pathak J, et al.
Commun Biol
. 2024 Aug;
7(1):972.
PMID: 39122786
Dental pulp stem cells (DPSC) have shown osteogenic and bone regenerative potential. Improving the in situ bone regeneration potential of DPSC is crucial for their application as seed cells during...
4.
Davie T, Serrat X, Imhof L, Snider J, Stagljar I, Keiser J, et al.
Nat Commun
. 2024 May;
15(1):3367.
PMID: 38719808
Soil-transmitted helminths (STHs) are major pathogens infecting over a billion people. There are few classes of anthelmintics and there is an urgent need for new drugs. Many STHs use an...
5.
Zhou J, Pathak J, Wu L, Chen B, Cao T, Wei W, et al.
Free Radic Biol Med
. 2024 Apr;
218:1-15.
PMID: 38574973
Sjogren's syndrome (SS) is an autoimmune disease characterized by dysfunction of exocrine glands, such as salivary glands. However, the molecular mechanism of salivary secretion dysfunction in SS is still unclear....
6.
Zhou J, Pathak J, Cao T, Chen B, Wei W, Hu S, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Mar;
1870(4):167121.
PMID: 38471652
Background: Sjögren's syndrome (SS) is a chronic autoimmune disease that predominantly affects exocrine glands. Previous studies have demonstrated that upregulated interferon-gamma (IFN-γ) in SS triggers ferroptosis in salivary gland epithelial...
7.
Liu X, Sanada E, Li J, Li X, Osada H, Watanabe N
Oncol Res
. 2023 Aug;
31(5):645-654.
PMID: 37547765
β-transducin repeat-containing protein (β-TrCP) is an F-box protein subunit of the E3 Skp1-Cullin-F box (SCF) type ubiquitin-ligase complex, and provides the substrate specificity for the ligase. To find potent ligands...
8.
Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc
Liu Z, Okano A, Sanada E, Futamura Y, Nogawa T, Ishikawa K, et al.
Oncol Res
. 2023 Aug;
31(5):655-666.
PMID: 37547761
Myc belongs to a family of proto-oncogenes that encode transcription factors. The overexpression of c-Myc causes many types of cancers. Recently, we established a system for screening c-Myc inhibitors and...
9.
Liu Z, Ishikawa K, Sanada E, Semba K, Li J, Li X, et al.
J Biol Chem
. 2023 Jul;
299(9):105083.
PMID: 37495110
c-Myc is a critical regulator of cell proliferation and growth. Elevated levels of c-Myc cause transcriptional amplification, leading to various types of cancers. Small molecules that specifically inhibit c-Myc-dependent regulation...
10.
Tan F, Ting A, Najimudin N, Watanabe N, Shamsuddin S, Zainuddin A, et al.
J Gerontol A Biol Sci Med Sci
. 2023 Jul;
78(11):1944-1952.
PMID: 37453137
Alzheimer's disease (AD) is the most prevalent type of dementia globally. The accumulation of amyloid-beta (Aβ) extracellular senile plaques in the brain is one of the hallmark mechanisms found in...