Nishith R Reddy
Overview
Explore the profile of Nishith R Reddy including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
86
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0
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Recent Articles
1.
Reddy N, Maachi H, Xiao Y, Simic M, Yu W, Tonai Y, et al.
Science
. 2024 Dec;
386(6726):eadl4793.
PMID: 39636990
Immune homeostasis requires a balance of inflammatory and suppressive activities. To design cells potentially useful for local immune suppression, we engineered conventional CD4 T cells with synthetic Notch (synNotch) receptors...
2.
Simic M, Watchmaker P, Gupta S, Wang Y, Sagan S, Duecker J, et al.
Science
. 2024 Dec;
386(6726):eadl4237.
PMID: 39636984
To engineer cells that can specifically target the central nervous system (CNS), we identified extracellular CNS-specific antigens, including components of the CNS extracellular matrix and surface molecules expressed on neurons...
3.
Allen G, Frankel N, Reddy N, Bhargava H, Yoshida M, Stark S, et al.
Science
. 2022 Dec;
378(6625):eaba1624.
PMID: 36520915
Chimeric antigen receptor (CAR) T cells are ineffective against solid tumors with immunosuppressive microenvironments. To overcome suppression, we engineered circuits in which tumor-specific synNotch receptors locally induce production of the...
4.
Newberry R, Arhar T, Costello J, Hartoularos G, Maxwell A, Naing Z, et al.
ACS Chem Biol
. 2020 Aug;
15(8):2137-2153.
PMID: 32786289
Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins remains largely uncharacterized, in part due to the challenge of probing protein...
5.
Gerardin J, Reddy N, Lim W
Cell Syst
. 2019 Sep;
9(3):297-308.e2.
PMID: 31521602
Many cellular responses for which timing is critical display temporal filtering-the ability to suppress response until stimulated for longer than a given minimal time. To identify biochemical circuits capable of...