Matthias Hebrok
Overview
Explore the profile of Matthias Hebrok including associated specialties, affiliations and a list of published articles.
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Articles
128
Citations
8807
Followers
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Recent Articles
1.
Reddy N, Maachi H, Xiao Y, Simic M, Yu W, Tonai Y, et al.
Science
. 2024 Dec;
386(6726):eadl4793.
PMID: 39636990
Immune homeostasis requires a balance of inflammatory and suppressive activities. To design cells potentially useful for local immune suppression, we engineered conventional CD4 T cells with synthetic Notch (synNotch) receptors...
2.
Hendley A, Ashe S, Urano A, Ng M, Phu T, Peng X, et al.
bioRxiv
. 2024 Oct;
PMID: 39399775
Graphical Abstract:
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Puri S, Maachi H, Nair G, Russ H, Chen R, Pulimeno P, et al.
Nat Commun
. 2024 Jan;
15(1):588.
PMID: 38238288
Despite significant research, mechanisms underlying the failure of islet beta cells that result in type 2 diabetes (T2D) are still under investigation. Here, we report that Sox9, a transcriptional regulator...
5.
Laklai H, Miroshnikova Y, Pickup M, Collisson E, Kim G, Barrett A, et al.
Nat Med
. 2023 Nov;
30(3):908.
PMID: 38017076
No abstract available.
6.
Ashe S, Hebrok M
Semin Nephrol
. 2023 Nov;
43(3):151432.
PMID: 37918206
Type 2 diabetes mellitus (T2D) has become a global epidemic affecting the health of millions of people. T2D is a complex and multifactorial metabolic disease, largely characterized by a combination...
7.
Cochrane V, Hebrok M
Nat Rev Endocrinol
. 2023 Oct;
19(12):681-682.
PMID: 37783847
No abstract available.
8.
Cha J, Tong X, Walker E, Dahan T, Cochrane V, Ashe S, et al.
JCI Insight
. 2023 Aug;
8(16).
PMID: 37606041
Type 2 diabetes (T2D) is associated with compromised identity of insulin-producing pancreatic islet β cells, characterized by inappropriate production of other islet cell-enriched hormones. Here, we examined how hormone misexpression...
9.
Chendke G, Kharbikar B, Ashe S, Faleo G, Sneddon J, Tang Q, et al.
Bioeng Transl Med
. 2023 Jul;
8(4):e10520.
PMID: 37476069
Beta cell replacement therapy (BCRT) for patients with type 1 diabetes (T1D) improves blood glucose regulation by replenishing the endogenous beta cells destroyed by autoimmune attack. Several limitations, including immune...
10.
de Klerk E, Xiao Y, Emfinger C, Keller M, Berrios D, Loconte V, et al.
JCI Insight
. 2023 Jun;
8(11).
PMID: 37288664
Insulin secretion from pancreatic β cells is essential to the maintenance of glucose homeostasis. Defects in this process result in diabetes. Identifying genetic regulators that impair insulin secretion is crucial...