Nikunj M Shukla
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Explore the profile of Nikunj M Shukla including associated specialties, affiliations and a list of published articles.
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35
Citations
679
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Recent Articles
1.
Belsuzarri M, Sako Y, Brown T, Chan M, Cozza R, Jin J, et al.
J Med Chem
. 2024 Aug;
67(16):13703-13722.
PMID: 39115891
Extracellular vesicles (EVs) can transfer antigens and immunomodulatory molecules, and such EVs released by antigen-presenting cells equipped with immunostimulatory functions have been utilized for vaccine formulations. A prior high-throughput screening...
2.
Sako Y, Sato-Kaneko F, Shukla N, Yao S, Belsuzarri M, Chan M, et al.
ACS Chem Biol
. 2023 Apr;
18(4):982-993.
PMID: 37039433
Extracellular vesicles (EVs) transfer antigens and immunomodulatory molecules in immunologic synapses as a part of intracellular communication, and EVs equipped with immunostimulatory functions have been utilized for vaccine formulation. Hence,...
3.
Sato-Kaneko F, Yao S, Lao F, Sako Y, Jin J, Shukla N, et al.
Vaccines (Basel)
. 2022 Oct;
10(10).
PMID: 36298559
Systemically vaccinated individuals against COVID-19 and influenza may continue to support viral replication and shedding in the upper airways, contributing to the spread of infections. Thus, a vaccine regimen that...
4.
Shukla N, Sato-Kaneko F, Yao S, Pu M, Chan M, Lao F, et al.
Front Pharmacol
. 2022 Apr;
13:869649.
PMID: 35479316
Extracellular vesicles (EVs) play an important role in intercellular communication and regulation of cells, especially in the immune system where EVs can participate in antigen presentation and may have adjuvant...
5.
Saito T, Shukla N, Sato-Kaneko F, Sako Y, Hosoya T, Yao S, et al.
ACS Chem Biol
. 2022 Jan;
17(1):217-229.
PMID: 34985883
There remains an unmet need for reliable fully synthetic adjuvants that increase lasting protective immune responses from vaccines. We previously reported a high-throughput screening for small molecules that extended nuclear...
6.
Saito T, Sako Y, Sato-Kaneko F, Hosoya T, Yao S, Lao F, et al.
Front Immunol
. 2021 Oct;
12:701445.
PMID: 34650551
As viruses continue to mutate the need for rapid high titer neutralizing antibody responses has been highlighted. To meet these emerging threats, agents that enhance vaccine adjuvant activity are needed...
7.
Shukla N, Chan M, Lao F, Chu P, Belsuzarri M, Yao S, et al.
Bioorg Med Chem
. 2021 Jul;
43:116242.
PMID: 34274759
In the face of emerging infectious diseases, there remains an unmet need for vaccine development where adjuvants that enhance immune responses to pathogenic antigens are highly desired. Using high-throughput screens...
8.
Sato-Kaneko F, Yao S, Lao F, Nan J, Shpigelman J, Cheng A, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(23).
PMID: 34078669
Vaccine adjuvants enhance and prolong pathogen-specific protective immune responses. Recent reports indicate that host factors-such as aging, pregnancy, and genetic polymorphisms-influence efficacies of vaccines adjuvanted with Toll-like receptor (TLR) or...
9.
Shpigelman J, Lao F, Yao S, Li C, Saito T, Sato-Kaneko F, et al.
Front Pharmacol
. 2021 May;
12:668609.
PMID: 33935791
Extracellular vesicles (EVs) are identified as mediators of intercellular communication and cellular regulation. In the immune system, EVs play a role in antigen presentation as a part of cellular communication....
10.
Hosoya T, Shukla N, Fujita Y, Yao S, Lao F, Baba H, et al.
Front Pharmacol
. 2021 Jan;
11:607713.
PMID: 33390996
In recent years target based drug discovery has expanded our therapeutic armamentarium in the treatment of inflammatory and autoimmune diseases. Despite these advances and adverse effects, glucocorticoids remain reliable agents...