Nigel Whitebread
Overview
Explore the profile of Nigel Whitebread including associated specialties, affiliations and a list of published articles.
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4
Citations
1718
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Recent Articles
1.
Peluso M, Campbell V, Harari J, Tibbitts T, Proctor J, Whitebread N, et al.
PLoS One
. 2014 Mar;
9(3):e90534.
PMID: 24608250
A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has...
2.
Smith S, Hoyt J, Whitebread N, Manna J, Peluso M, Faia K, et al.
Xenobiotica
. 2013 Mar;
43(10):875-85.
PMID: 23527529
1. IPI-926 is a novel semisynthetic cyclopamine derivative that is a potent and selective Smoothened inhibitor that blocks the hedgehog signal transduction pathway. 2. The in vivo clearance of IPI-926...
3.
Tillotson B, Slocum K, Coco J, Whitebread N, Thomas B, West K, et al.
J Biol Chem
. 2010 Oct;
285(51):39835-43.
PMID: 20940293
Several Hsp90 (heat shock protein 90) inhibitors are currently under clinical evaluation as anticancer agents. However, the correlation between the duration and magnitude of Hsp90 inhibition and the downstream effects...
4.
Olive K, Jacobetz M, Davidson C, Gopinathan A, McIntyre D, Honess D, et al.
Science
. 2009 May;
324(5933):1457-61.
PMID: 19460966
Pancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers in part because it is insensitive to many chemotherapeutic drugs. Studying a mouse model of PDA that is refractory...