Nigel P Birch
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Explore the profile of Nigel P Birch including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
431
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Recent Articles
1.
Loef E, Sheppard H, Birch N, Dunbar P
J Biol Chem
. 2022 Jun;
298(7):102112.
PMID: 35690148
Plasmin is a broad-spectrum protease and therefore needs to be tightly regulated. Active plasmin is formed from plasminogen, which is found in high concentrations in the blood and is converted...
2.
Loef E, Sheppard H, Birch N, Dunbar P
Front Immunol
. 2021 Apr;
12:628090.
PMID: 33841411
The ability to study migratory behavior of immune cells is crucial to understanding the dynamic control of the immune system. Migration induced by chemokines is often assumed to be directional...
3.
Wette S, Birch N, Soop M, Zugel M, Murphy R, Lamb G, et al.
J Appl Physiol (1985)
. 2020 Dec;
130(3):545-561.
PMID: 33356984
Little is known about the molecular responses to power resistance exercise that lead to skeletal muscle remodeling and enhanced athletic performance. We assessed the expression of titin-linked putative mechanosensing proteins...
4.
Park S, Brooks A, Chen C, Sheppard H, Loef E, McIntosh J, et al.
Immunol Cell Biol
. 2020 Aug;
99(1):49-64.
PMID: 32740978
B-cell migration within lymph nodes (LNs) is crucial to adaptive immune responses. Chemotactic gradients are proposed to drive migration of B cells into follicles, followed by their relocation to specific...
5.
Loef E, Brooks A, Lorenz N, Birch N, Dunbar P
J Leukoc Biol
. 2019 Nov;
107(1):145-158.
PMID: 31667914
T cells play a key role in mounting an adaptive immune response. T cells are activated upon recognition of cognate Ag presented by an APC. Subsequently, T cells adhere to...
6.
Ng J, Kaur H, Collier T, Chang K, Brooks A, Allison J, et al.
J Biol Chem
. 2019 Apr;
294(22):8806-8818.
PMID: 30996005
Aβ1-42 is involved in Alzheimer's disease (AD) pathogenesis and is prone to glycation, an irreversible process where proteins accumulate advanced glycated end products (AGEs). -(Carboxyethyl)lysine (CEL) is a common AGE...
7.
Kasim J, Kavianinia I, Ng J, Harris P, Birch N, Brimble M
Org Biomol Chem
. 2018 Dec;
17(1):30-34.
PMID: 30500032
The amyloidogenic Aβ42 peptide was efficiently prepared using a double linker system, markedly improving solubility and chromatographic peak resolution, thus enabling full characterisation using standard techniques. The tag was readily...
8.
Ren H, Birch N, Suresh V
PLoS One
. 2016 Oct;
11(10):e0165225.
PMID: 27780255
Robust and reproducible in vitro models are required for investigating the pathways involved in fluid homeostasis in the human alveolar epithelium. We performed functional and phenotypic characterisation of ion transport...
9.
Lee T, Tsang V, Loef E, Birch N
Semin Cell Dev Biol
. 2016 Sep;
62:152-159.
PMID: 27639894
It is 27 years since neuroserpin was first discovered in the nervous system and identified as a member of the serpin superfamily. Since that time potential roles for this serine...
10.
Cheng Y, Loh Y, Birch N
J Mol Neurosci
. 2016 Aug;
61(1):123-131.
PMID: 27510267
Oxidative stress plays a critical role in neuronal injury and is associated with various neurological diseases. Here, we explored the potential protective effect of neuroserpin against oxidative stress in primary...