Hilary M Sheppard
Overview
Explore the profile of Hilary M Sheppard including associated specialties, affiliations and a list of published articles.
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14
Citations
196
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Recent Articles
1.
Cloarec-Ung F, Beaulieu J, Suthananthan A, Lehnertz B, Sauvageau G, Sheppard H, et al.
Elife
. 2024 Jun;
12.
PMID: 38829685
Precision gene editing in primary hematopoietic stem and progenitor cells (HSPCs) would facilitate both curative treatments for monogenic disorders as well as disease modelling. Precise efficiencies even with the CRISPR/Cas...
2.
Hunt J, Samson C, du Rand A, Sheppard H
Hum Genet
. 2023 Apr;
142(6):705-720.
PMID: 37093294
Genome editing using the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein (Cas) gene-editing system (CRISPR-Cas) is a valuable tool for fundamental and applied research applications. Significant improvements...
3.
du Rand A, Hunt J, Feisst V, Sheppard H
Mol Diagn Ther
. 2022 Oct;
26(6):627-643.
PMID: 36251245
Skin wound healing is a crucial process for regenerating healthy skin and avoiding the undesired consequences associated with open skin wounds. For epidermolysis bullosa (EB), a debilitating group of fragile...
4.
Loef E, Sheppard H, Birch N, Dunbar P
J Biol Chem
. 2022 Jun;
298(7):102112.
PMID: 35690148
Plasmin is a broad-spectrum protease and therefore needs to be tightly regulated. Active plasmin is formed from plasminogen, which is found in high concentrations in the blood and is converted...
5.
Loef E, Sheppard H, Birch N, Dunbar P
Front Immunol
. 2021 Apr;
12:628090.
PMID: 33841411
The ability to study migratory behavior of immune cells is crucial to understanding the dynamic control of the immune system. Migration induced by chemokines is often assumed to be directional...
6.
Park S, Brooks A, Chen C, Sheppard H, Loef E, McIntosh J, et al.
Immunol Cell Biol
. 2020 Aug;
99(1):49-64.
PMID: 32740978
B-cell migration within lymph nodes (LNs) is crucial to adaptive immune responses. Chemotactic gradients are proposed to drive migration of B cells into follicles, followed by their relocation to specific...
7.
Brooks A, Iminitoff M, Williams E, Damani T, Jackson-Patel V, Fan V, et al.
Front Pharmacol
. 2020 Mar;
10:1695.
PMID: 32153389
Human adipose-derived mesenchymal stromal cells (ASC) are showing clinical promise for the treatment of a range of inflammatory and degenerative conditions. These lipoaspirate-derived cells are part of the abundant and...
8.
Iminitoff M, Damani T, Williams E, Brooks A, Feisst V, Sheppard H
Int J Mol Sci
. 2020 Feb;
21(4).
PMID: 32098272
There is clinical interest in using human adipose tissue-derived mesenchymal stromal cells (ASC) to treat a range of inflammatory and regenerative conditions. Aspects of ASC biology, including their regenerative potential...
9.
Michaels Y, Barnkob M, Barbosa H, Baeumler T, Thompson M, Andre V, et al.
Nat Commun
. 2019 Jun;
10(1):2622.
PMID: 31182710
Following re-sequencing of the miSFIT constructs used in the paper, two of the construct variants inserted into the 3'UTR of PD-1, namely '12C' and '17A, 18G', have been found to...
10.
Michaels Y, Barnkob M, Barbosa H, Baeumler T, Thompson M, Andre V, et al.
Nat Commun
. 2019 Feb;
10(1):818.
PMID: 30778069
Precise, analogue regulation of gene expression is critical for cellular function in mammals. In contrast, widely employed experimental and therapeutic approaches such as knock-in/out strategies are more suitable for binary...