Nigel M Williams
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Explore the profile of Nigel M Williams including associated specialties, affiliations and a list of published articles.
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91
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7913
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Recent Articles
21.
Jabbari E, Holland N, Chelban V, Jones P, Lamb R, Rawlinson C, et al.
JAMA Neurol
. 2019 Dec;
77(3):377-387.
PMID: 31860007
Importance: Atypical parkinsonian syndromes (APS), including progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), may be difficult to distinguish in early stages and are often misdiagnosed...
22.
Tan M, Malek N, Lawton M, Hubbard L, Pittman A, Joseph T, et al.
Brain
. 2019 Jul;
142(9):2828-2844.
PMID: 31324919
Our objective was to define the prevalence and clinical features of genetic Parkinson's disease in a large UK population-based cohort, the largest multicentre prospective clinico-genetic incident study in the world....
23.
Jabbari E, Woodside J, Tan M, Pavese N, Bandmann O, Ghosh B, et al.
Mov Disord
. 2019 Jul;
34(9):1307-1314.
PMID: 31299107
Background: Studies on early-onset presentations of progressive supranuclear palsy (PSP) have been limited to those where a rare monogenic cause has been identified. Here, we have defined early-onset PSP (EOPSP)...
24.
Jones H, Hubbard L, Mitchell R, Jones S, Williams N, Zammit S, et al.
JAMA Netw Open
. 2019 Jun;
2(6):e196118.
PMID: 31225891
Importance: The association of rheumatoid arthritis (RA) with cognitive and psychiatric phenotypes has been recognized. However, it is not known whether these phenotypes are a consequence of disease-related factors, such...
25.
Malek N, Kanavou S, Lawton M, Pitz V, Grosset K, Bajaj N, et al.
Parkinsonism Relat Disord
. 2019 May;
65:55-61.
PMID: 31105012
Background: L-dopa responsiveness in Parkinson's disease (PD) varies, but the clinical correlates and significance of this are ill-defined. Methods: Patients were assessed before and after their usual morning L-dopa dose,...
26.
Twohig J, Cardus Figueras A, Andrews R, Wiede F, Cossins B, Derrac Soria A, et al.
Nat Immunol
. 2019 Mar;
20(4):458-470.
PMID: 30890796
The cytokine IL-6 controls the survival, proliferation and effector characteristics of lymphocytes through activation of the transcription factors STAT1 and STAT3. While STAT3 activity is an ever-present feature of IL-6...
27.
Malek N, Lawton M, Grosset K, Bajaj N, Barker R, Burn D, et al.
Mov Disord Clin Pract
. 2018 Oct;
4(4):509-516.
PMID: 30363477
Background: Autonomic dysfunction is common in the later stages of Parkinson's disease (PD), but less is known about its presence and severity in early disease. Objective: To analyze features of...
28.
Bakhsh A, Ladas I, Hamshere M, Bullock M, Kirov G, Zhang L, et al.
Thyroid
. 2018 Jun;
28(7):891-901.
PMID: 29897006
Background: Euthyroid multinodular goiter (MNG) is common, but little is known about the genetic variations conferring predisposition. Previously, a family with MNG of adolescent onset was reported in which some...
29.
Boot E, Butcher N, Udow S, Marras C, Mok K, Kaneko S, et al.
Neurology
. 2018 May;
90(23):e2059-e2067.
PMID: 29752303
Objective: To delineate the natural history, diagnosis, and treatment response of Parkinson disease (PD) in individuals with 22q11.2 deletion syndrome (22q11.2DS), and to determine if these patients differ from those...
30.
Jansen I, Gibbs J, Nalls M, Price T, Lubbe S, van Rooij J, et al.
Neurobiol Aging
. 2017 Sep;
59:220.e11-220.e18.
PMID: 28867149
Many common genetic factors have been identified to contribute to Parkinson's disease (PD) susceptibility, improving our understanding of the related underlying biological mechanisms. The involvement of rarer variants in these...