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Nigel M Williams

Explore the profile of Nigel M Williams including associated specialties, affiliations and a list of published articles. Areas
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Articles 91
Citations 7913
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Recent Articles
11.
Hrastelj J, Andrews R, Loveless S, Morgan J, Bishop S, Bray N, et al.
Brain Commun . 2021 Nov; 3(3):fcab155. PMID: 34761221
The CNS has traditionally been considered an immune privileged site, but is now understood to have a system of immune surveillance, predominantly involving CD4 T-cells. Identifying functional differences between CNS...
12.
Owen M, Williams N
World Psychiatry . 2021 May; 20(2):294-295. PMID: 34002520
No abstract available.
13.
McAllister B, Gusella J, Landwehrmeyer G, Lee J, MacDonald M, Orth M, et al.
Neurology . 2021 Mar; 96(19):e2395-e2406. PMID: 33766994
Objective: To assess the prevalence, timing, and functional impact of psychiatric, cognitive, and motor abnormalities in Huntington disease (HD) gene carriers, we analyzed retrospective clinical data from individuals with manifest...
14.
Lubbe S, Bustos B, Hu J, Krainc D, Joseph T, Hehir J, et al.
Hum Mol Genet . 2021 Jan; 30(1):78-86. PMID: 33448283
Biallelic Parkin (PRKN) mutations cause autosomal recessive Parkinson's disease (PD); however, the role of monoallelic PRKN mutations as a risk factor for PD remains unclear. We investigated the role of...
15.
Choompoo N, Bartley O, Precious S, Vinh N, Schnell C, Garcia A, et al.
Cytotherapy . 2020 Nov; 23(2):111-118. PMID: 33246883
Background: Cell replacement therapy (CRT) for Huntington disease (HD) requires a source of striatal (STR) progenitors capable of restoring the function lost due to STR degeneration. Authentic STR progenitors can...
16.
Davies R, Fiksinski A, Breetvelt E, Williams N, Hooper S, Monfeuga T, et al.
Nat Med . 2020 Nov; 26(12):1912-1918. PMID: 33169016
The 22q11.2 deletion syndrome (22q11DS) is associated with a 20-25% risk of schizophrenia. In a cohort of 962 individuals with 22q11DS, we examined the shared genetic basis between schizophrenia and...
17.
Tan M, Lawton M, Jabbari E, Reynolds R, Iwaki H, Blauwendraat C, et al.
Mov Disord . 2020 Oct; 36(2):424-433. PMID: 33111402
Background: There are currently no treatments that stop or slow the progression of Parkinson's disease (PD). Case-control genome-wide association studies have identified variants associated with disease risk, but not progression....
18.
Brown E, Blauwendraat C, Trinh J, Rizig M, Nalls M, Leveille E, et al.
Neurobiol Aging . 2020 Sep; 97:148.e17-148.e24. PMID: 32873436
The LRRK2 gene has rare (p.G2019S) and common risk variants for Parkinson's disease (PD). DNM3 has previously been reported as a genetic modifier of the age at onset in PD...
19.
Williams N, Hubbard L, Sandor C, Webber C, Hendry H, Lawton M, et al.
Mov Disord . 2020 Feb; 35(4):705-707. PMID: 32078185
No abstract available.
20.
Cleynen I, Engchuan W, Hestand M, Heung T, Holleman A, Johnston H, et al.
Mol Psychiatry . 2020 Feb; 26(8):4496-4510. PMID: 32015465
Schizophrenia occurs in about one in four individuals with 22q11.2 deletion syndrome (22q11.2DS). The aim of this International Brain and Behavior 22q11.2DS Consortium (IBBC) study was to identify genetic factors...