Nicolle Besselink
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Explore the profile of Nicolle Besselink including associated specialties, affiliations and a list of published articles.
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12
Citations
604
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Recent Articles
1.
Chen L, Jager M, Rebergen D, Brink G, Ende T, Vanderlinden W, et al.
Genome Res
. 2025 Jan;
PMID: 39805703
Shallow genome-wide cell-free DNA (cfDNA) sequencing holds great promise for non-invasive cancer monitoring by providing reliable copy number alteration (CNA) and fragmentomic profiles. Single nucleotide variations (SNVs) are, however, much...
2.
Besselink N, Keijer J, Vermeulen C, Boymans S, de Ridder J, Van Hoeck A, et al.
Sci Rep
. 2023 Apr;
13(1):6874.
PMID: 37106015
DNA methylation is important for establishing and maintaining cell identity and for genomic stability. This is achieved by regulating the accessibility of regulatory and transcriptional elements and the compaction of...
3.
Vlaar J, Borgman A, Kalkhoven E, Westland D, Besselink N, Shale C, et al.
Sci Rep
. 2022 Jun;
12(1):10081.
PMID: 35710704
Bladder cancer has a high recurrence rate and low survival of advanced stage patients. Few genetic drivers of bladder cancer have thus far been identified. We performed in-depth structural variant...
4.
Nguyen L, Jager M, Lieshout R, de Ruiter P, Locati M, Besselink N, et al.
Commun Biol
. 2021 Nov;
4(1):1301.
PMID: 34795391
Inflammatory liver disease increases the risk of developing primary liver cancer. The mechanism through which liver disease induces tumorigenesis remains unclear, but is thought to occur via increased mutagenesis. Here,...
5.
Cameron D, Baber J, Shale C, Espejo Valle-Inclan J, Besselink N, Van Hoeck A, et al.
Genome Biol
. 2021 Jul;
22(1):202.
PMID: 34253237
GRIDSS2 is the first structural variant caller to explicitly report single breakends-breakpoints in which only one side can be unambiguously determined. By treating single breakends as a fundamental genomic rearrangement...
6.
Kuijk E, Jager M, van der Roest B, Locati M, Van Hoeck A, Korzelius J, et al.
Nat Commun
. 2020 Aug;
11(1):3932.
PMID: 32753580
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
7.
Kuijk E, Jager M, van der Roest B, Locati M, Van Hoeck A, Korzelius J, et al.
Nat Commun
. 2020 May;
11(1):2493.
PMID: 32427826
Genetic changes acquired during in vitro culture pose a risk for the successful application of stem cells in regenerative medicine. To assess the genetic risks induced by culturing, we determined...
8.
Middelkamp S, Vlaar J, Giltay J, Korzelius J, Besselink N, Boymans S, et al.
Genome Med
. 2019 Dec;
11(1):79.
PMID: 31801603
Background: Genomic structural variants (SVs) can affect many genes and regulatory elements. Therefore, the molecular mechanisms driving the phenotypes of patients carrying de novo SVs are frequently unknown. Methods: We...
9.
Christensen S, van der Roest B, Besselink N, Janssen R, Boymans S, Martens J, et al.
Nat Commun
. 2019 Oct;
10(1):4571.
PMID: 31594944
5-Fluorouracil (5-FU) is a chemotherapeutic drug commonly used for the treatment of solid cancers. It is proposed that 5-FU interferes with nucleotide synthesis and incorporates into DNA, which may have...
10.
Jager M, Blokzijl F, Kuijk E, Bertl J, Vougioukalaki M, Janssen R, et al.
Genome Res
. 2019 Jun;
29(7):1067-1077.
PMID: 31221724
Nucleotide excision repair (NER) is one of the main DNA repair pathways that protect cells against genomic damage. Disruption of this pathway can contribute to the development of cancer and...