Ewart Kuijk
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Explore the profile of Ewart Kuijk including associated specialties, affiliations and a list of published articles.
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21
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1231
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Recent Articles
1.
de Vries M, de Vries M, Meddens C, Meddens C, Hijma H, Hijma H, et al.
bioRxiv
. 2025 Feb;
PMID: 39975165
Intestinal epithelial cells (IECs) are capable of mounting an adequate antimicrobial inflammatory response to pathogens while tolerating commensals. The underlying regulatory mechanisms of immune sensitivity remain incompletely understood, particularly in...
2.
TTC7A missense variants in intestinal disease can be classified by molecular and cellular phenotypes
Shojaei Jeshvaghani Z, Mijnders M, Muffels I, van Beekhuizen S, Kotlarz D, Lindemans C, et al.
Hum Mol Genet
. 2024 Dec;
34(4):313-326.
PMID: 39675053
Biallelic mutations in tetratricopeptide repeat domain 7A (TTC7A) give rise to intestinal and immune disorders. However, our understanding of the genotype-phenotype relationship is limited, because TTC7A variants are mostly compound...
3.
Bui B, Ardisasmita A, Kuijk E, Altmae S, Steba G, Mackens S, et al.
Hum Reprod
. 2023 Dec;
39(2):275-281.
PMID: 38099857
Infertility is a complex condition affecting millions of couples worldwide. The current definition of infertility, based on clinical criteria, fails to account for the molecular and cellular changes that may...
4.
Besselink N, Keijer J, Vermeulen C, Boymans S, de Ridder J, Van Hoeck A, et al.
Sci Rep
. 2023 Apr;
13(1):6874.
PMID: 37106015
DNA methylation is important for establishing and maintaining cell identity and for genomic stability. This is achieved by regulating the accessibility of regulatory and transcriptional elements and the compaction of...
5.
Kuijk E, Kranenburg O, Cuppen E, Van Hoeck A
Nat Commun
. 2022 Oct;
13(1):5915.
PMID: 36207433
Genome-wide mutation analyses have revealed that specific anti-cancer drugs are highly mutagenic to cancer cells, but the mutational impact of anti-cancer therapies on normal cells is not known. Here, we...
6.
Vlaar J, Borgman A, Kalkhoven E, Westland D, Besselink N, Shale C, et al.
Sci Rep
. 2022 Jun;
12(1):10081.
PMID: 35710704
Bladder cancer has a high recurrence rate and low survival of advanced stage patients. Few genetic drivers of bladder cancer have thus far been identified. We performed in-depth structural variant...
7.
Vougioukalaki M, Demmers J, Vermeij W, Baar M, Bruens S, Magaraki A, et al.
Aging Cell
. 2022 Mar;
21(4):e13562.
PMID: 35246937
Organs age differently, causing wide heterogeneity in multimorbidity, but underlying mechanisms are largely elusive. To investigate the basis of organ-specific ageing, we utilized progeroid repair-deficient Ercc1 mouse mutants and systematically...
8.
Hasaart K, Manders F, Ubels J, Verheul M, van Roosmalen M, Groenen N, et al.
iScience
. 2022 Feb;
25(2):103736.
PMID: 35118356
Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, but genetic instability is a major concern. Embryonic pluripotent cells also accumulate mutations during early development, but how this...
9.
Nguyen L, Jager M, Lieshout R, de Ruiter P, Locati M, Besselink N, et al.
Commun Biol
. 2021 Nov;
4(1):1301.
PMID: 34795391
Inflammatory liver disease increases the risk of developing primary liver cancer. The mechanism through which liver disease induces tumorigenesis remains unclear, but is thought to occur via increased mutagenesis. Here,...
10.
Kuijk E, Jager M, van der Roest B, Locati M, Van Hoeck A, Korzelius J, et al.
Nat Commun
. 2020 Aug;
11(1):3932.
PMID: 32753580
An amendment to this paper has been published and can be accessed via a link at the top of the paper.