Nicole Therville
Overview
Explore the profile of Nicole Therville including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
32
Citations
464
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0
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Recent Articles
1.
Bourdais A, Viard P, Bormann J, Sesboue C, Guerrier D, Therville N, et al.
Development
. 2025 Feb;
PMID: 39982048
The PI3K/Akt pathway is thought to regulate key steps of mammalian oogenesis, such as dormant oocyte awakening during follicular activation, meiotic resumption and oocyte maturation. Supporting evidence is however indirect,...
2.
Di-Luoffo M, Schmitter C, Barrere E, Therville N, Chaouki M, DAngelo R, et al.
Life Sci Alliance
. 2025 Jan;
8(3).
PMID: 39746759
Mechanical stresses, including compression, arise during cancer progression. In solid cancer, especially breast and pancreatic cancers, the rapid tumor growth and the environment remodeling explain their high intensity of compressive...
3.
Dubot P, Astudillo L, Therville N, Carrie L, Pettazzoni M, Cheillan D, et al.
Cancers (Basel)
. 2022 Oct;
14(19).
PMID: 36230781
Sphingolipids play a key structural role in cellular membranes and/or act as signaling molecules. Inherited defects of their catabolism lead to lysosomal storage diseases called sphingolipidoses. Although progress has been...
4.
Cintas C, Douche T, Dantes Z, Mouton-Barbosa E, Bousquet M, Cayron C, et al.
Mol Cancer Ther
. 2021 Sep;
20(12):2433-2445.
PMID: 34552006
The PI3K pathway is highly active in human cancers. The four class I isoforms of PI3K are activated by distinct mechanisms leading to a common downstream signaling. Their downstream redundancy...
5.
Thibault B, Ramos-Delgado F, Pons-Tostivint E, Therville N, Cintas C, Arcucci S, et al.
EMBO Mol Med
. 2021 May;
13(7):e13502.
PMID: 34033220
Pancreatic ductal adenocarcinoma (PDAC) patients frequently suffer from undetected micro-metastatic disease. This clinical situation would greatly benefit from additional investigation. Therefore, we set out to identify key signalling events that...
6.
Arcucci S, Ramos-Delgado F, Cayron C, Therville N, Gratacap M, Basset C, et al.
Biochem J
. 2021 Mar;
478(6):1199-1225.
PMID: 33740047
PI3Ks are important lipid kinases that produce phosphoinositides phosphorylated in position 3 of the inositol ring. There are three classes of PI3Ks: class I PI3Ks produce PIP3 at plasma membrane...
7.
Montfort A, Bertrand F, Rochotte J, Gilhodes J, Filleron T, Milhes J, et al.
Cancer Immunol Res
. 2021 Mar;
9(5):568-582.
PMID: 33727246
Dysregulation of lipid metabolism affects the behavior of cancer cells, but how this happens is not completely understood. Neutral sphingomyelinase 2 (nSMase2), encoded by , catalyzes the breakdown of sphingomyelin...
8.
Dubot P, Astudillo L, Therville N, Sabourdy F, Stirnemann J, Levade T, et al.
Cancers (Basel)
. 2020 Feb;
12(2).
PMID: 32085512
The roles of ceramide and its catabolites, i.e., sphingosine and sphingosine 1-phosphate, in the development of malignancies and the response to anticancer regimens have been extensively described. Moreover, an abundant...
9.
Zamora A, Alves M, Chollet C, Therville N, Fougeray T, Tatin F, et al.
Cell Death Dis
. 2019 Dec;
10(12):956.
PMID: 31863036
Cytotoxic therapy for breast cancer inhibits the growth of primary tumors, but promotes metastasis to the sentinel lymph nodes through the lymphatic system. However, the effect of first-line chemotherapy on...
10.
Therville N, Arcucci S, Vertut A, Ramos-Delgado F, Ferreira Da Mota D, Dufresne M, et al.
Theranostics
. 2019 Oct;
9(22):6369-6379.
PMID: 31588223
Rapid, easy and early pancreatic cancer diagnosis and therapeutic follow up continue to necessitate an increasing attention towards the development of effective treatment strategies for this lethal disease. The non...