Nicolas Viphakone
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Explore the profile of Nicolas Viphakone including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
506
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Recent Articles
1.
Viphakone N, Sudbery I, Griffith L, Heath C, Sims D, Wilson S
Mol Cell
. 2019 May;
75(2):310-323.e8.
PMID: 31104896
During gene expression, RNA export factors are mainly known for driving nucleo-cytoplasmic transport. While early studies suggested that the exon junction complex (EJC) provides a binding platform for them, subsequent...
2.
Lesbirel S, Viphakone N, Parker M, Parker J, Heath C, Sudbery I, et al.
Sci Rep
. 2018 Sep;
8(1):13827.
PMID: 30218090
N-methyladenosine (mA) is the most abundant internal modification of eukaryotic mRNA. This modification has previously been shown to alter the export kinetics for mRNAs though the molecular details surrounding this...
3.
Heath C, Viphakone N, Wilson S
Biochem J
. 2016 Sep;
473(19):2911-35.
PMID: 27679854
TRanscription and EXport (TREX) is a conserved multisubunit complex essential for embryogenesis, organogenesis and cellular differentiation throughout life. By linking transcription, mRNA processing and export together, it exerts a physiologically...
4.
Viphakone N, Cumberbatch M, Livingstone M, Heath P, Dickman M, Catto J, et al.
Nucleic Acids Res
. 2015 Feb;
43(4):2353-66.
PMID: 25662211
Cancer testis antigens (CTAs) represented a poorly characterized group of proteins whose expression is normally restricted to testis but are frequently up-regulated in cancer cells. Here we show that one...
5.
Chang C, Hautbergue G, Walsh M, Viphakone N, van Dijk T, Philipsen S, et al.
EMBO J
. 2013 Jan;
32(3):473-86.
PMID: 23299939
The TREX complex couples nuclear pre-mRNA processing with mRNA export and contains multiple protein components, including Uap56, Alyref, Cip29 and the multi-subunit THO complex. Here, we have identified Chtop as...
6.
Viphakone N, Hautbergue G, Walsh M, Chang C, Holland A, Folco E, et al.
Nat Commun
. 2012 Aug;
3:1006.
PMID: 22893130
The metazoan TREX complex is recruited to mRNA during nuclear RNA processing and functions in exporting mRNA to the cytoplasm. Nxf1 is an mRNA export receptor, which binds processed mRNA...
7.
Haddad R, Maurice F, Viphakone N, Voisinet-Hakil F, Fribourg S, Minvielle-Sebastia L
Nucleic Acids Res
. 2011 Oct;
40(3):1226-39.
PMID: 21993300
Polyadenylation is a co-transcriptional process that modifies mRNA 3'-ends in eukaryotes. In yeast, CF IA and CPF constitute the core 3'-end maturation complex. CF IA comprises Rna14p, Rna15p, Pcf11p and...
8.
Viphakone N, Voisinet-Hakil F, Minvielle-Sebastia L
Nucleic Acids Res
. 2008 Feb;
36(7):2418-33.
PMID: 18304944
In eukaryotic cells, newly synthesized mRNAs acquire a poly(A) tail that plays several fundamental roles in export, translation and mRNA decay. In mammals, PABPN1 controls the processivity of polyadenylation and...
9.
Dheur S, NyKamp K, Viphakone N, Swanson M, Minvielle-Sebastia L
J Biol Chem
. 2005 May;
280(26):24532-8.
PMID: 15894541
Regulation of poly(A) tail length during mRNA 3'-end formation requires a specific poly(A)-binding protein in addition to the cleavage/polyadenylation machinery. The mechanism that controls polyadenylation in mammals is well understood...