Sjaak Philipsen
Overview
Explore the profile of Sjaak Philipsen including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
108
Citations
3682
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Jaiteh Z, van der Linden R, Kong-A-San J, Maas A, Philipsen S, Grosveld F, et al.
Transfus Apher Sci
. 2025 Feb;
64(2):104092.
PMID: 39922087
Erythropoiesis is a process that requires tight control of gene transcription, mRNA stability, and protein synthesis and degradation. These regulatory layers adapt dynamically to developmental needs and physiological stresses, ensuring...
2.
Stephanou C, Menzel S, Philipsen S, Kountouris P
Int J Mol Sci
. 2024 Nov;
25(21).
PMID: 39518961
Elevated fetal hemoglobin (HbF), which is partly controlled by genetic modifiers, ameliorates disease severity in β hemoglobinopathies. Understanding the genetic basis of this trait holds great promise for personalized therapeutic...
3.
Verheul T, Gillemans N, Putzker K, Majied R, Li T, Vasiliou M, et al.
Hemasphere
. 2024 Aug;
8(8):e139.
PMID: 39108322
Reactivation of fetal hemoglobin expression alleviates the symptoms associated with β-globinopathies, severe hereditary diseases with significant global health implications due to their high morbidity and mortality rates. The symptoms emerge...
4.
Bieker J, Philipsen S
Adv Exp Med Biol
. 2024 Jul;
1459:217-242.
PMID: 39017846
Erythroid Krüppel-like factor (KLF1), first discovered in 1992, is an erythroid-restricted transcription factor (TF) that is essential for terminal differentiation of erythroid progenitors. At face value, KLF1 is a rather...
5.
Zhang H, Hansen M, Di Summa F, von Lindern M, Gillemans N, van IJcken W, et al.
Haematologica
. 2024 Jul;
109(12):3975-3988.
PMID: 38961746
Differentiation of induced pluripotent stem cells (iPSC) into hematopoietic lineages offers great therapeutic potential. During embryogenesis, hemogenic endothelium (HE) gives rise to hematopoietic stem and progenitor cells through the endothelial-...
6.
Lu H, Jiang X, He L, Ji X, Li X, Liu S, et al.
Nat Commun
. 2023 Sep;
14(1):5891.
PMID: 37735515
Endothelial dysfunction represents a major cardiovascular risk factor for hypertension. Sp1 and Sp3 belong to the specificity protein and Krüppel-like transcription factor families. They are ubiquitously expressed and closely associated...
7.
Lu H, Yuan P, Ma X, Jiang X, Liu S, Ma C, et al.
Nat Commun
. 2023 May;
14(1):2371.
PMID: 37185975
No abstract available.
8.
Lu H, Yuan P, Ma X, Jiang X, Liu S, Ma C, et al.
Nat Commun
. 2023 Feb;
14(1):731.
PMID: 36759621
Angiogenesis is a critical pathophysiological process involved in organ growth and various diseases. Transcription factors Sp1/Sp3 are necessary for fetal development and tumor growth. Sp1/Sp3 proteins were downregulated in the...
9.
Buoninfante O, Pilzecker B, Spanjaard A, de Groot D, Prekovic S, Song J, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(4):e2216055120.
PMID: 36669105
DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance (DDT), which is regulated via PCNA ubiquitination and REV1....
10.
Cruz L, Rezaei S, Grosveld F, Philipsen S, Eich C
Front Genome Ed
. 2022 Nov;
4:1030285.
PMID: 36407494
Modern-day hematopoietic stem cell (HSC) therapies, such as gene therapy, modify autologous HSCs prior to re-infusion into myelo-conditioned patients and hold great promise for treatment of hematological disorders. While this...