Ian Sudbery
Overview
Explore the profile of Ian Sudbery including associated specialties, affiliations and a list of published articles.
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17
Citations
2257
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Recent Articles
1.
Watson S, Porter H, Sudbery I, Thompson R
Int J Mol Sci
. 2024 May;
25(9).
PMID: 38731808
Single-cell RNA sequencing (scRNAseq) is a rapidly advancing field enabling the characterisation of heterogeneous gene expression profiles within a population. The cell cycle phase is a major contributor to gene...
2.
Moss C, Johnston S, Kimble J, Clements M, Codd V, Hamby S, et al.
Cell Rep
. 2024 Apr;
43(4):114073.
PMID: 38578825
Macrophages are central innate immune cells whose function declines with age. The molecular mechanisms underlying age-related changes remain poorly understood, particularly in human macrophages. We report a substantial reduction in...
3.
Baquero-Perez B, Yonchev I, Delgado-Tejedor A, Medina R, Puig-Torrents M, Sudbery I, et al.
Nat Commun
. 2024 Mar;
15(1):1964.
PMID: 38467633
Despite the nuclear localization of the mA machinery, the genomes of multiple exclusively-cytoplasmic RNA viruses, such as chikungunya (CHIKV) and dengue (DENV), are reported to be extensively mA-modified. However, these...
4.
Ray S, Abugable A, Parker J, Liversidge K, Palminha N, Liao C, et al.
Nature
. 2022 Sep;
609(7929):1038-1047.
PMID: 36171374
Oxidative genome damage is an unavoidable consequence of cellular metabolism. It arises at gene regulatory elements by epigenetic demethylation during transcriptional activation. Here we show that promoters are protected from...
5.
Baidzajevas K, Hadadi E, Lee B, Lum J, Shihui F, Sudbery I, et al.
Atherosclerosis
. 2020 Jun;
305:10-18.
PMID: 32592946
Background And Aims: Lipid-rich foam cell macrophages drive atherosclerosis via several mechanisms, including inflammation, lipid uptake, lipid deposition and plaque vulnerability. The atheroma environment shapes macrophage function and phenotype; anti-inflammatory...
6.
Viphakone N, Sudbery I, Griffith L, Heath C, Sims D, Wilson S
Mol Cell
. 2019 May;
75(2):310-323.e8.
PMID: 31104896
During gene expression, RNA export factors are mainly known for driving nucleo-cytoplasmic transport. While early studies suggested that the exon junction complex (EJC) provides a binding platform for them, subsequent...
7.
Srivastava A, Malik L, Smith T, Sudbery I, Patro R
Genome Biol
. 2019 Mar;
20(1):65.
PMID: 30917859
We introduce alevin, a fast end-to-end pipeline to process droplet-based single-cell RNA sequencing data, performing cell barcode detection, read mapping, unique molecular identifier (UMI) deduplication, gene count estimation, and cell...
8.
Lesbirel S, Viphakone N, Parker M, Parker J, Heath C, Sudbery I, et al.
Sci Rep
. 2018 Sep;
8(1):13827.
PMID: 30218090
N-methyladenosine (mA) is the most abundant internal modification of eukaryotic mRNA. This modification has previously been shown to alter the export kinetics for mRNAs though the molecular details surrounding this...
9.
Liao C, Beveridge R, Hudson J, Parker J, Chiang S, Ray S, et al.
Cell Rep
. 2018 Jun;
23(11):3352-3365.
PMID: 29898404
Genomic damage can feature DNA-protein crosslinks whereby their acute accumulation is utilized to treat cancer and progressive accumulation causes neurodegeneration. This is typified by tyrosyl DNA phosphodiesterase 1 (TDP1), which...
10.
Smith T, Heger A, Sudbery I
Genome Res
. 2017 Jan;
27(3):491-499.
PMID: 28100584
Unique Molecular Identifiers (UMIs) are random oligonucleotide barcodes that are increasingly used in high-throughput sequencing experiments. Through a UMI, identical copies arising from distinct molecules can be distinguished from those...